Clonal Tracking and Nuclear Identity of Genetically Engineered Cells

Using barcoding for the in vivo clonal tracking of genetically engineered cells and retroviral scanning for the characterization of cellular genetic and nuclear identity

Our laboratory seeks to elucidate the mechanisms and dynamics involved in the clonal selection of gene-modified cells in human beings after gene therapy. We are studying the vector-host interactions occurring in the target cells upon genetic modification and we are using retroviral scanning in combination with single-cell transcriptome and epigenome analyses for the discovery of cell-specific chromatin and nuclear states in human cells.