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Active Grants and Sponsored Research

Sponsor Grant ID: 5R01HL130793-02 Project Date: September 10, 2015 - May 31, 2019
Sponsoring Organization: National Institutes Of Health (NIH)

Megakaryocyte Transcription Factor Activation to Enhance In Vitro Platelet Production from Human IPSCs

Description of Major Goals
The overall goal of this project is to investigate signaling pathways that activate megakaryocyte transcription factors as a means to enhance the efficiency of platelet production of human IPS cells.
Project Date: January 16, 2017 - January 15, 2019
Sponsoring Organization: Alex's Lemonade Stand Foundation and Babich Family Foundation

Pharmacologic Enhancement of Residual Wild Type RUNX1 Protein Activity in FPD/AML

Description of Major Goals
The goal of this project is to identify small molecules that enhance residual wild type protein in individuals with germline heterozygous RUNX1 inactivating mutations in Familial Platelet Disorder with Propensity to Develop
Sponsor Grant ID: W81XWH-16-1-0616 Project Date: September 30, 2016 - September 29, 2018
Sponsoring Organization: Department of Defense

Genetic Risk Factors for Clonal Hematopoiesis and Leukemia Development Following Ionizing Radiation and Chemical Exposure

Description of Major Goals
The overall goal of this project is to test the hypothesis that genotoxic stress (ionizing radiation, DNA damaging chemicals, etc.) selects for pre-existing hematopoietic stem/progenitor cells that contain mutations in genes, such as RUNX1, that activate the DNA damage response pathway. This will be tested in a whole animal model. In addition, a CRISPR/Cas9 screen will be used to identify novel genes involved in this pathway.
Sponsor Grant ID: 5K12HL087164-10 Project Date: September 1, 2012 - May 31, 2018
Sponsoring Organization: National Insititutes of Health

Clinical Hematology Research Career Development Award

Description of Major Goals
The major goal of this project is to support training in clinical research for non-malignant hematology. The long-term goal of this career development grant is to attract and retain talented young physician scientists to the field of blood diseases.
Sponsor Grant ID: 429618 Project Date: July 01, 2016 - December 31, 2017
Sponsoring Organization: St. Baldrick'S Foundation

Role of GATA2 Dysregulation in Juvenile Myelmonocytic Leukemia

Description of Major Goals
Juvenile myelomonocytic leukemia is an aggressive blood cancer of young children. The only current curative treatment is bone marrow transplantation, Yet, about 50% of children still die from their disease despite this very aggressive therapy. An improved understanding of the mechanisms that cause JMML is critical to developing new treatments. Based on recent work, we hypothesize that a protein called GATA2, which normally turns on and off white blood cell genes, is erroneously activated in JMML. This proposal is designed to test this hypothesis. Positive results would support development of medicines to inhibit GATA2 for the treatment of JMML.
Sponsor Grant ID: 5R01DK098448-03 Project Date: September 15, 2013 - November 30, 2017
Sponsoring Organization: National Institutes Of Health (NIH)

Regulation of RUNX1 Multiprotein Complex Formation during Hematopoiesis

Description of Major Goals
The overall goal of this project is to further understand the mechanisms and signaling pathways that modulate RUNX1 protein-protein interactions during cellular differentiation.
Project Date: October 1, 2016 - September 30, 2017
Sponsoring Organization: Harvard Stem Cell Institute

HSCI FACS Core Facility Award

Description of Major Goals
This grant is to support a core facility that isolates normal and leukemia stem cells for investigators a Boston Children’s Hospital and the Harvard Stem Cell Institute.
Sponsor Grant ID: N/A Project Date: July 1, 2015 - September 30, 2017
Sponsoring Organization: Alex's Lemonade Stand Foundation

Transcriptional Effectors of Activated RAS Signaling in Juvenile Myelomonocytic Leukemia

Description of Major Goals
The goal of this project is to test the role of RUNX1 as a dysregulated transcriptional effect target of activated RAS/Shp2 signaling in Juvenile Myelomonocytic Leukemia.
Sponsor Grant ID: 5P01HL032262-34 Project Date: August 15, 2011 - April 15, 2017
Sponsoring Organization: National Heart, Lung And Blood Institute (NHLBI)

Developmental Biology of Human Erythropoiesis: Project 4

Description of Major Goals
The overall goal of this program project grant is to further understand the molecular regulation of erythroid development in humans. Dr. Cantor’s project involves elucidating the mechanisms by which GATA-1, a master erythroid transcription factor, distinguishes between direct target genes to activate versus repress and how it carries out these opposing transcriptional outputs in a gene context-dependent manner.