The overarching goal of Dr. Kean’s research is to understand mechanisms underlying immune tolerance-induction in the prevention and treatment of allo-and auto-immune diseases, with projects focused on graft-versus-host disease (GvHD), transplant rejection, T cell mediators of protective immunity, and the mechanisms underlying auto-immune diseases of the GI tract. Dr. Kean’s work has led to the creation of several innovative non-human primate models of T cell-mediated immune pathology and to several first-in-disease clinical trials. She has used both the animal models and the mechanistic studies linked to her clinical trials to investigate the cellular and molecular mechanisms of immune reconstitution, GvHD and transplant rejection, and to test the impact that novel immunosuppressive therapies can make on these processes.
Highly motivated applicants with a PhD degree in immunology, pathophysiology or a related field are invited to apply.
The candidate must be independent in scientific research and writing, self-motivated, ethical, team spirited, and must have exceptional laboratory, communication, organizational, and writing skills.
- Strong background in basic molecular, cellular and immunological techniques (primary cell harvesting and culturing; PCR methods; immunophenotyping and functional assays using polychromatic flow cytometry) is essential.
- Experience/interest in systems biology and computational methods is desirable.
Boston Children’s Hospital or Dana Farber Cancer Institute are an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
300 Longwood Avenue
Boston, MA 02115
- Research and Science