Postdoctoral Fellow / Graduate Student
Boston Children’s Hospital
Harvard Medical School
Fellowship in functional genomics and genome editing of human hematopoiesis
Bauer Laboratory, Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School
The Bauer laboratory seeks highly motivated post-doctoral research fellows and graduate students to study the functional genomics of human hematopoiesis. We are interested to identify and explore the genetic determinants of blood cell development, homeostasis, and disease. We use molecular genetic, biochemical, and genome editing methodologies to perturb and observe blood cells. We have identified regulatory elements that are subject to naturally occurring disease associated genetic variation and are critical determinants of fetal hemoglobin level and hemoglobin disorder clinical severity. We have developed methodologies for high-throughput and high-resolution functional evaluation of coding and noncoding genetic elements. Our studies are meant to elucidate fundamental mechanisms of gene regulatory elements in their endogenous chromosomal environment and to define structure-function relationships of disease relevant protein complexes. A major motivation of our work is to translate findings into novel therapies for patients with blood disorders. We are advancing therapeutic gene editing from preclinical studies to first-in-human trials for blood disorders with unmet clinical need.
Interested applicants should send a CV, cover letter, statement of research interest and contact information for three references via email to Daniel Bauer, MD PhD (firstname.lastname@example.org), Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA. Boston Children’s Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of Harvard Medical School. The Bauer Laboratory is also affiliated with the Dana-Farber Cancer Institute, Harvard Stem Cell Institute, and Broad Institute of Harvard and MIT.
Prior experience in molecular and cell biology, genetics, biochemistry, gene therapy, hematopoiesis, systems biology, structural/chemical biology, and/or bioinformatics/computational biology is highly desirable. The candidate must be independent in scientific research and writing, self-motivated, ethical, team spirited, and must have exceptional laboratory, communication, organizational, and writing skills.
Boston Children’s Hospital or Dana Farber Cancer Institute are an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.
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