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Active Grants and Sponsored Research

Sponsor Grant ID: 1R01HL124209-01A1 Project Date: December 1, 2014 - November 30, 2019
Sponsoring Organization: National Institutes Of Health (NIH)

Defining the roles of RIPK1 and RIPK3 in emergency hematopoiesis

Description of Major Goals
The major goal of this project is to understand how the negative regulation of necroptosis by RIPK1 and the positive regulation of necroptosis by RIPK3 affects hematopoieiss at steady state and following transplantation and infection. Aim 1b and Aim 3a have some overlap with this application.
Sponsor Grant ID: 84133 Project Date: April 1, 2016 - March 31, 2019
Sponsoring Organization: GABRIELLE'S ANGEL FUND FOR CANCER RESRCH

Gene editing in ALL to promote immunomodulatory forms of lytic cell death

Description of Major Goals
We propose to use CRISPR-Cas9 gene editing to eliminate RIPK1 (a negative regulator of necroptosis), as well as pharmacological approaches to access the necroptosis cascade. This research investigates the effects of necroptosis on leukemogenesis.
Sponsor Grant ID: 77661 Project Date: September 01, 2016 - August 31, 2018
Sponsoring Organization: Alex’s Lemonade Stand Foundation

Gene editing in T cell leukemia to promote immunomodulatory forms of death

Description of Major Goals
This research proposal will combine a panel of SMAC mimetics to increase the immunogenicity of cancer cell death and a panel of antibodies to suppress immune checkpoints in T cells to promote anti-tumor immunity. There is no overlap with this application.
Sponsor Grant ID: 83204 Project Date: June 01, 2016 - May 31, 2018
Sponsoring Organization: American Asthma Foundation Research Program

Non-apoptotic death of neutrophils and eosinophils drives allergic asthma

Description of Major Goals
The major goal of this research is to understand how neutrophil lifespan is affected in the setting of asthma and pulmonary infection, and the role of immunomodulatory forms of cell death. There is no overlap with this application.