IAP inhibition sensitizes neutrophils to TNF but not LPS-mediated cell death and IL-1β secretion
MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
Gerlic M, Croker B
McArthur K, D'Cruz AA, Segal D, Lackovic K, Wilks AF, O'Donnell JA, Nowell CJ, Gerlic M, Huang DCS , Burns CJ, Croker B
Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis.
Zargarian S, Shlomovitz I, Erlich Z, Hourizadeh A, Ofir-Birin Y, Croker B, Regev-Rudzki N, Edry-Botzer L, Gerlic M
A Helicobacter pylori Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization
Hutton ML, D'Costa K, Rossiter A, Wang L, Turner L, Steer DL, Masters SL, Croker B, Kaparakis-Liaskos M, Ferrero RL,
Bliss-Moreau M, Chen AA, D'Cruz AA, Croker B
Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee M, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker B, Febbraio MA, Masters SL
Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3.
Liu X, Liu R, Croker B, Lawlor KE, Smyth GK, Wicks IP
Croker B, Silke J, Gerlic M
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.
Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts A, Kastner DL, Lew AM, Lyras D, Kile BT, Croker B, Masters SL
O'Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Zhang JG, O'Reilly LA, Cengia L, Dias S, Masters SL, Hartland EL, Roberts A, Gerlic M, Croker B
Aberrant actin-depolymerization leads to caspase-1 activation and IL-18 dependent autoinflammatory disease in redears mice
Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts A, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker B, Gerlic M, Silke J
Croker B, Gerlic , Masters , Moayeri , Cengia , Kile
Pyroptotic death storms and cytopenia.
Croker B, Gerlic , O'Donnell
Neutrophil survival in the death zone.
Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O'Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker B
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor
Croker B, LINDQVIST , Vikstrom , Chambers , McArthur , Ann Anderson , Henley , Happo , Cluse , Johnston , Roberts , Kile , Croker , Burns , Rizzacasa , Strasser , Huang
ENU-induced phenovariance in mice: inferences from 587 mutations
Croker B, Kiu H, Pellegrini M, Toe J, Preston S, Metcalf D, O'Donnell JA, Cengia LH, McArthur K, Nicola NA, Alexander WS, Roberts A
The role of neutrophils during mild and severe influenza virus infections of mice
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
Croker B, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts A
Croker B, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts A
A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways.
Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production.
Masters SL, Mielke LA, Cornish AL, Sutton CE, O'Donnell J, Cengia LH, Roberts A, Wicks IP, Mills KH, Croker B
A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.
Croker B, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA
Croker B, Kiu H, Nicholson SE
Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.
Croker B, Mielke LA, Wormald S, Metcalf D, Kiu H, Alexander WS, Hilton DJ, Roberts A
Opposing roles of gp130 mediated STAT-3 and ERK-1/2 signalling in liver progenitor cell migration and proliferation.
Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, Eleftherianos I, Imler JL, Beutler B
Genetic analysis of host resistance: Toll-like receptor signalling and immunity at large.
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.
Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination.
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
Genetic analysis of innate resistance to mouse cytomegalovirus
The Jak-Stat Pathway of Cytokine Signaling
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Croker B, Metcalf D, Robb L, Wei W, Mifsud S, DiRago L, Cluse LA, Sutherland KD, Hartley L, Williams E, Zhang JG, Hilton DJ, Nicola NA, Alexander WS, Roberts A
Croker B, Hart A
Croker B, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, Robb L, Greenhalgh CJ, Förster I, Clausen BE, Nicola NA, Metcalf D, Hilton DJ, Roberts A, Alexander WS
Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses.
Croker B, Handman E, Hayball JD, Baldwin TM, Voigt V, Cluse LA, Yang FC, Williams D, Roberts A
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.
Croker B, Tarlinton DM, Cluse LA, Tuxen AJ, Light A, Yang FC, Williams D, Roberts A
Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.
Kile BT, Viney EM, Willson TA, Brodnicki TC, Cancilla MR, Herlihy AS, Croker B, Baca M, Nicola NA, Hilton DJ, Alexander WS