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Publications

Manuscript: Journal of Immunology

IAP inhibition sensitizes neutrophils to TNF but not LPS-mediated cell death and IL-1β secretion

Year: 2018

MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

Journal Article: Nature immunology Year: 2017
Issue: 9 Volume: 18 Page: 953-954

Myelopoiesis embraces its inner weakness. 

Gerlic M, Croker B
Journal Article: Oncotarget Year: 2017
Issue: 35 Volume: 8 Page: 57948-57963

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia. 

McArthur K, D'Cruz AA, Segal D, Lackovic K, Wilks AF, O'Donnell JA, Nowell CJ, Gerlic M, Huang DCS , Burns CJ, Croker B
Journal Article: PLoS biology Year: 2017
Issue: 6 Volume: 15 Page: e2002711

Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis. 

Zargarian S, Shlomovitz I, Erlich Z, Hourizadeh A, Ofir-Birin Y, Croker B, Regev-Rudzki N, Edry-Botzer L, Gerlic M
Manuscript: Frontiers in Cellular and Infection Microbiology Issue: 254543

A Helicobacter pylori Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization

Hutton ML, D'Costa K, Rossiter A, Wang L, Turner L, Steer DL, Masters SL, Croker B, Kaparakis-Liaskos M, Ferrero RL,
Journal Article: Immunology and cell biology Year: 2017
Issue: 2 Volume: 95 Page: 146-151

A motive for killing: effector functions of regulated lytic cell death. 

Bliss-Moreau M, Chen AA, D'Cruz AA, Croker B
Journal Article: Cell metabolism Year: 2016
Issue: 1 Volume: 23 Page: 155-64

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome. 

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee M, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker B, Febbraio MA, Masters SL
Journal Article: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Year: 2015
Issue: 10 Volume: 23 Page: 1743-54

Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3. 

Liu X, Liu R, Croker B, Lawlor KE, Smyth GK, Wicks IP
Journal Article: Current opinion in hematology Year: 2015
Issue: 4 Volume: 22 Page: 293-301

Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis. 

Croker B, Silke J, Gerlic M
Journal Article: The Journal of experimental medicine Year: 2015
Issue: 6 Volume: 212 Page: 927-38

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β. 

Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts A, Kastner DL, Lew AM, Lyras D, Kile BT, Croker B, Masters SL
Manuscript: Nature Communications Year: 2015
Volume: 18 Page: 6282

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL 

Croker B
Journal Article: Journal of leukocyte biology Year: 2015
Issue: 2 Volume: 97 Page: 321-6

Fas regulates neutrophil lifespan during viral and bacterial infection. 

O'Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Zhang JG, O'Reilly LA, Cengia L, Dias S, Masters SL, Hartland EL, Roberts A, Gerlic M, Croker B
Manuscript: Journal Experimental Medicine

Aberrant actin-depolymerization leads to caspase-1 activation and IL-18 dependent autoinflammatory disease in redears mice

Croker B
Journal Article: Cell Year: 2014
Issue: 5 Volume: 157 Page: 1175-88

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. 

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts A, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker B, Gerlic M, Silke J
Manuscript: Cell Metabolism Year: 2014
Issue: 3 Volume: 19 Page: 345

NLRP1a expression in Srebp-1a-deficient mice 

Croker B, Gerlic , Masters , Moayeri , Cengia , Kile
Manuscript: Pyroptotic death storms and cytopenia. Year: 2014
Volume: 26 Page: 128

Pyroptotic death storms and cytopenia.

Croker B, Gerlic , O'Donnell
Manuscript: Blood Year: 2014
Issue: 3 Volume: 123 Page: 307

Neutrophil survival in the death zone.

Croker B
Journal Article: Immunity Year: 2012
Issue: 6 Volume: 37 Page: 1009-23

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. 

Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O'Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker B
Manuscript: Cell Death Dis Year: 2012
Issue: 3 Volume: 11 Page: e409

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor 

Croker B, LINDQVIST , Vikstrom , Chambers , McArthur , Ann Anderson , Henley , Happo , Cluse , Johnston , Roberts , Kile , Croker , Burns , Rizzacasa , Strasser , Huang
Year: 2012

ENU-induced phenovariance in mice: inferences from 587 mutations

Journal Article: Immunology and cell biology Year: 2012
Issue: 1 Volume: 90 Page: 124-9

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3. 

Croker B, Kiu H, Pellegrini M, Toe J, Preston S, Metcalf D, O'Donnell JA, Cengia LH, McArthur K, Nicola NA, Alexander WS, Roberts A
Year: 2011

The role of neutrophils during mild and severe influenza virus infections of mice

Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2011
Issue: 32 Volume: 108 Page: 13135-40

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. 

Croker B, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts A
Journal Article: Journal of immunology (Baltimore, Md. : 1950) Year: 2011
Issue: 2 Volume: 186 Page: 1131-9

Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. 

Croker B, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts A
Year: 2010
Issue: 11 Page: 335-43

A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Year: 2010
Issue: 185 Page: 2125-33

Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways.

Journal Article: EMBO reports Year: 2010
Issue: 8 Volume: 11 Page: 640-6

Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production. 

Masters SL, Mielke LA, Cornish AL, Sutton CE, O'Donnell J, Cengia LH, Roberts A, Wicks IP, Mills KH, Croker B
Year: 2008
Issue: 112 Page: 5193-5201

A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis

Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2008
Issue: 39 Volume: 105 Page: 15028-33

Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. 

Croker B, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA
Journal Article: Seminars in cell & developmental biology Year: 2008
Issue: 4 Volume: 19 Page: 414-22

SOCS regulation of the JAK/STAT signalling pathway. 

Croker B, Kiu H, Nicholson SE
Journal Article: Experimental hematology Year: 2008
Issue: 7 Volume: 36 Page: 786-98

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation. 

Croker B, Mielke LA, Wormald S, Metcalf D, Kiu H, Alexander WS, Hilton DJ, Roberts A
Year: 2007
Issue: 45 Page: 486-94

Opposing roles of gp130 mediated STAT-3 and ERK-1/2 signalling in liver progenitor cell migration and proliferation.

Journal Article: Nature genetics Year: 2007
Issue: 12 Volume: 39 Page: 1453-60

ATP-sensitive potassium channels mediate survival during infection in mammals and insects. 

Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, Eleftherianos I, Imler JL, Beutler B
Year: 2006
Issue: 24 Page: 353-89

Genetic analysis of host resistance: Toll-like receptor signalling and immunity at large.

Year: 2006
Issue: 116 Page: 1571-81

SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.

Year: 2006
Issue: 103 Page: 7859-64

Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination.

Year: 2006
Issue: 103 Page: 16442-7

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

Year: 2005
Issue: 4(3) Page: 203-13

Genetic analysis of innate resistance to mouse cytomegalovirus

Book Chapter: Humana Press Year: 2004
Issue: 1 Volume: 1 Page: 45-64

The Jak-Stat Pathway of Cytokine Signaling

Croker B
Journal Article: Immunity Year: 2004
Issue: 2 Volume: 20 Page: 153-65

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. 

Croker B, Metcalf D, Robb L, Wei W, Mifsud S, DiRago L, Cluse LA, Sutherland KD, Hartley L, Williams E, Zhang JG, Hilton DJ, Nicola NA, Alexander WS, Roberts A
Journal Article: Genome Biology Year: 2003
Issue: 5 Volume: 4 Page: 318

Croker B, Hart A
Journal Article: Nature immunology Year: 2003
Issue: 6 Volume: 4 Page: 540-5

SOCS3 negatively regulates IL-6 signaling in vivo. 

Croker B, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, Robb L, Greenhalgh CJ, Förster I, Clausen BE, Nicola NA, Metcalf D, Hilton DJ, Roberts A, Alexander WS
Journal Article: Immunology and cell biology Year: 2002
Issue: 3 Volume: 80 Page: 231-40

Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses. 

Croker B, Handman E, Hayball JD, Baldwin TM, Voigt V, Cluse LA, Yang FC, Williams D, Roberts A
Journal Article: Journal of immunology (Baltimore, Md. : 1950) Year: 2002
Issue: 7 Volume: 168 Page: 3376-86

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. 

Croker B, Tarlinton DM, Cluse LA, Tuxen AJ, Light A, Yang FC, Williams D, Roberts A
Journal Article: Gene Year: 2000
Issue: 1-2 Volume: 258 Page: 31-41

Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. 

Kile BT, Viney EM, Willson TA, Brodnicki TC, Cancilla MR, Herlihy AS, Croker B, Baca M, Nicola NA, Hilton DJ, Alexander WS