Pyroptosis is a non-apoptotic form of cell death that aids in the clearance of intracellular bacteria and viral infection. Pyroptosis of hematopoietic stem and progenitor cells can induce cytopenia, immunosuppression and bone marrow failure. This research investigates the molecular regulators of the NLRP1 inflammasome.



c165e0_05b256dcbdd14c2db9891f3ecffff7a8Neutrophil death

Humans produce 100 billion neutrophils every day, and even more following infection, so what types of cell death balance this production to prevent chronic inflammation? The laboratory studies the types of cell death controlling neutrophil numbers at steady-state and during infection and inflammation.




Bone marrow transplantation is a major treatment modality for cancer patientsc165e0_1665968f927e4c37aaafd8d3594e759c who have undergone chemotherapy. However, a return to full immunocompetence after transplant takes up to 2 years, leaving patients vulnerable to life-threatening infection. Activation of necroptosis in this setting is under investigation.



Cancer immunotherapy

c165e0_a57db12e82d04709a6a78d9bbe3dc01bmv2Cell death removes damaged, pre-cancerous, and infected cells. Chemotherapeutics typically activate cell death but do not alert the immune system to the presence of cancer. We will harness a novel type of cell death that can promote immune responses against leukemic cells.