Clinical Trial of SP-C2577 (Seclidemstat) in Patients with Relapsed or Refractory Ewing SarcomaDescription of Major Goals
This funding supports Dr. Crompton’s participation on this clinical trial as part of the National Pediatric Cancer Foundation’s “Sunshine Project,” which implements a novel collaborative approach that will accelerate the development of new drugs and therapies leading to the prevention and cure of pediatric cancers.
Targeting kinase signaling in preclinical models of Ewing sarcomaDescription of Major Goals
The major goals of this project are pre-clinical validation of AURKB inhibitors and identification of rational combination studies for the implementation of these drugs into an early phase clinical trial for patients with Ewing sarcoma.
Development of Liquid Biopsy Assays for Wilms TumorDescription of Major Goals
The goal of this project is to develop a circulating tumor DNA assay that utilizes peripheral blood draws to quantify DNA released from the tumors into the blood stream as a surrogate for measuring tumor burden, treatment response, and monitoring for relapse in patients with Wims tumor.