Targeting kinase signaling in preclinical models of Ewing sarcomaDescription of Major Goals
The major goals of this project are to determine the cellular mechanisms that are effected by the combination of FAK and AURKB inhibition in Ewing sarcoma cells. We believe that understanding these interactions could lead to the discovery of additional therapeutically targets for patients with this aggressive pediatric cancer.
Targeting FAK and integrin signaling in preclinical models of Ewing sarcomaDescription of Major Goals
This project examines the hypotheses that Ewing sarcoma is dependent on ITGB2 signaling, that adhesion molecules are critical for the development of metastasis, and that Aurora B kinase inhibition could be a potent targeted approach for combination therapy with FAK inhibition in the treatment of Ewing sarcoma.
Pilot Study for ctDNA AnalysisDescription of Major Goals
The goal of this project is to detect circulating tumor DNA levels in patients with Ewing sarcoma who were enrolled on a phase I study and correlate levels with treatment responses.
Development of a Circulating Tumor DNA Assay for LeiomyosarcomaDescription of Major Goals
The goal of this project is to detect circulating tumor DNA levels in patients with leiomyosarcoma who were enrolled on a multi-institutional prospective trial and determine whether levels correspond to outcomes.