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Active Grants and Sponsored Research

Sponsor Grant ID: Independent Investigator Grant Project Date: July 01, 2017 - June 30, 2020
Sponsoring Organization: Rally Foundation

Targeting kinase signaling in preclinical models of Ewing sarcoma

Description of Major Goals
The major goals of this project are to determine the cellular mechanisms that are effected by the combination of FAK and AURKB inhibition in Ewing sarcoma cells. We believe that understanding these interactions could lead to the discovery of additional therapeutically targets for patients with this aggressive pediatric cancer.
Sponsor Grant ID: K08 CA188073 Project Date: July 07, 2015 - June 30, 2020
Sponsoring Organization: NIH/NCI

Targeting FAK and integrin signaling in preclinical models of Ewing sarcoma

Description of Major Goals
This project examines the hypotheses that Ewing sarcoma is dependent on ITGB2 signaling, that adhesion molecules are critical for the development of metastasis, and that Aurora B kinase inhibition could be a potent targeted approach for combination therapy with FAK inhibition in the treatment of Ewing sarcoma.
Sponsor Grant ID: SRA #A12128 Project Date: October 04, 2018 - October 03, 2019
Sponsoring Organization: Gradalis Inc.

Pilot Study for ctDNA Analysis

Description of Major Goals
The goal of this project is to detect circulating tumor DNA levels in patients with Ewing sarcoma who were enrolled on a phase I study and correlate levels with treatment responses.
Project Date: September 06, 2018 - September 05, 2019
Sponsoring Organization: SARC Demonstration Project

Development of a Circulating Tumor DNA Assay for Leiomyosarcoma

Description of Major Goals
The goal of this project is to detect circulating tumor DNA levels in patients with leiomyosarcoma who were enrolled on a multi-institutional prospective trial and determine whether levels correspond to outcomes.