Publications
High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma.
Wang S, Hwang EE, Guha R, O'Neill AF, Melong N, Veinotte CJ, Saur Conway A, Wuerthele K, Shen M, McKnight C, Alexe G, Lemieux ME, Wang A, Hughes E, Xu X, Boxer MB, Hall MD, Kung AL, Berman JN, Davis M, Stegmaier K, Crompton B
Volume: 8
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
Hong AL, Tseng YY, Wala JA, Kim W, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, Ward A, McSteen B, Labella KM, Keskula P, Tracy A, Connor C, Clinton CM, Church AJ, Crompton B, Janeway K, Van Hare B, Sandak D, Gjoerup O, Bandopadhayay P, Clemons PA, Schreiber SL, Root DE, Gokhale PC, Chi S, Mullen E, Roberts C, Kadoch C, Beroukhim R, Ligon KL, Boehm JS, Hahn WC
Page: e27595
Assessment of circulating tumor DNA in pediatric solid tumors: The promise of liquid biopsies.
Abbou SD, Shulman D, DuBois SG, Crompton B
Volume: 2019
Detection of Circulating Tumor DNA in Patients With Leiomyosarcoma With Progressive Disease.
Hemming ML, Klega KS, Rhoades J, Ha G, Acker KE, Andersen JL, Thai E, Nag A, Thorner AR, Raut CP, George S, Crompton B
Issue: 5 Volume: 119 Page: 615-621
Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group.
Shulman D, Klega K, Imamovic-Tuco A, Clapp A, Nag A, Thorner AR, Van Allen E, Ha G, Lessnick SL, Gorlick R, Janeway K, Leavey PJ, Mascarenhas L, London W, Vo KT, Stegmaier K, Hall D, Krailo MD, Barkauskas DA, DuBois SG, Crompton B
Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma with SP-2509 engages the endoplasmic reticulum stress response.
Pishas KI, Drenberg CD, Taslim C, Theisen ER, Johnson KM, Saund RS, Pop IL, Crompton B, Lawlor ER, Tirode F, Mora J, Delattre O, Beckerle MC, Callen DF, Sharma S, Lessnick SL
Volume: 2018
Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid Tumors.
Klega K, Imamovic-Tuco A, Ha G, Clapp AN, Meyer S, Ward A, Clinton C, Nag A, Van Allen E, Mullen E, DuBois SG, Janeway K, Meyerson M, Thorner AR, Crompton B
DFCI Protocol 17-104, Pediatric Solid Tumor Banking Protocol
Issue: 12 Volume: 12 Page: e0188835
Blood collection in cell-stabilizing tubes does not impact germline DNA quality for pediatric patients.
Wollison BM, Thai E, Mckinney A, Ward A, Clapp A, Clinton C, Nag A, Thorner AR, Gastier-Foster JM, Crompton B
Issue: 11 Volume: 63 Page: 1974-82
Patient/parent perspectives on genomic tumor profiling of pediatric solid tumors: The Individualized Cancer Therapy (iCat) experience.
Marron J, DuBois SG, Glade Bender J, Kim A, Crompton B, Meyer SC, Janeway K, Mack J
Volume: 7 Page: 11987
Integrated genetic and pharmacologic interrogation of rare cancers.
Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, Kryukov GV, Clemons PA, Tsherniak A, Vazquez F, Crompton B, Shamji AF, Rodriguez-Galindo C, Janeway K, Roberts C, Stegmaier K, van Hummelen P, Cima MJ, Langer RS, Garraway LA, Schreiber SL, Root DE, Hahn WC, Boehm JS
Issue: 5 Volume: 209 Page: 182-94
Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop.
Hingorani P, Janeway K, Crompton B, Kadoch C, Mackall CL, Khan J, Shern JF, Schiffman J, Mirabello L, Savage SA, Ladanyi M, Meltzer P, Bult CJ, Adamson PC, Lupo PJ, Mody R, DuBois SG, Parsons DW, Khanna C, Lau C, Hawkins DS, Randall RL, Smith M, Sorensen PH, Plon SE, Skapek SX, Lessnick S, Gorlick R, Reed DR
Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study.
Harris MH, DuBois SG, Glade Bender JL, Kim A, Crompton B, Parker E, Dumont IP, Hong AL, Guo D, Church A, Stegmaier K, Roberts C, Shusterman S, London W, MacConaill LE, Lindeman NI, Diller L, Rodriguez-Galindo C, Janeway K
DFCI Protocol 15-169, Multicenter Cohort Study to Evaluate Outcomes after Receipt of Targeted Therapy Matched to an Individualized Cancer Therapy Recommendations,
Issue: 30 Volume: 6 Page: 30178-93
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.
Kennedy A, Vallurupalli M, Chen L, Crompton B, Cowley G, Vazquez F, Weir BA, Tsherniak A, Parasuraman S, Kim S, Alexe G, Stegmaier K
Volume: 24 Page: 91-6
CSF 5-Methyltetrahydrofolate Serial Monitoring to Guide Treatment of Congenital Folate Malabsorption Due to Proton-Coupled Folate Transporter (PCFT) Deficiency.
Torres A, Newton SA, Crompton B, Borzutzky A, Neufeld E, Notarangelo L, Berry G
Issue: 12 Volume: 124 Page: 5275-90
Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.
Marques Howarth M, Simpson D, Ngok SP, Nieves B, Chen R, Siprashvili Z, Vaka D, Breese MR, Crompton B, Alexe G, Hawkins DS, Jacobson D, Brunner AL, West R, Mora J, Stegmaier K, Khavari P, Sweet-Cordero EA
Issue: 11 Volume: 4 Page: 1326-41
The genomic landscape of pediatric Ewing sarcoma.
Crompton B, Stewart C, Taylor-Weiner A, Alexe G, Kurek KC, Calicchio ML, Kiezun A, Carter SL, Shukla SA, Mehta S, Thorner AR, de Torres C, Lavarino C, Suñol M, McKenna A, Sivachenko A, Cibulskis K, Lawrence MS, Stojanov P, Rosenberg M, Ambrogio L, Auclair D, Seepo S, Blumenstiel B, DeFelice M, Imaz-Rosshandler I, Schwarz-Cruz Celis A, Rivera MN, Rodriguez-Galindo C, Fleming MD, Golub T, Getz G, Mora J, Stegmaier K
Issue: 7457 Volume: 499 Page: 214-8
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Lee RS, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts C, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub T, Gordenin DA, Sunyaev S, Lander ES, Getz G
Issue: 9 Volume: 73 Page: 2873-83
High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma.
Crompton B, Carlton AL, Thorner AR, Christie AL, Du J, Calicchio ML, Rivera MN, Fleming MD, Kohl NE, Kung AL, Stegmaier K
Issue: 3 Volume: 133 Page: 287-94
Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter.
Borzutzky A, Crompton B, Bergmann AK, Giliani S, Baxi S, Martin M, Neufeld E, Notarangelo L
Issue: 3 Volume: 47 Page: 255-9
Survival after recurrence of osteosarcoma: a 20-year experience at a single institution.
Crompton B, Goldsby RE, Weinberg VK, Feren R, O'Donnell RJ, Ablin AR