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Publications

Duality of Purpose: Participant and Parent Understanding of the Purpose of Genomic Tumor Profiling Research Among Children and Young Adults With Solid Tumors

Provocative Questions in osteosarcoma basic and translational biology: a report from the Children’s Oncology Group.

Journal Article: Clinical cancer research : an official journal of the American Association for Cancer Research Year: 2019

High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma. 

Wang S, Hwang EE, Guha R, O'Neill AF, Melong N, Veinotte CJ, Saur Conway A, Wuerthele K, Shen M, McKnight C, Alexe G, Lemieux ME, Wang A, Hughes E, Xu X, Boxer MB, Hall MD, Kung AL, Berman JN, Davis M, Stegmaier K, Crompton B
Journal Article: eLife Year: 2019
Volume: 8

Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. 

Hong AL, Tseng YY, Wala JA, Kim W, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, Ward A, McSteen B, Labella KM, Keskula P, Tracy A, Connor C, Clinton CM, Church AJ, Crompton B, Janeway K, Van Hare B, Sandak D, Gjoerup O, Bandopadhayay P, Clemons PA, Schreiber SL, Root DE, Gokhale PC, Chi S, Mullen E, Roberts C, Kadoch C, Beroukhim R, Ligon KL, Boehm JS, Hahn WC
Journal Article: Pediatric blood & cancer Year: 2019
Page: e27595

Assessment of circulating tumor DNA in pediatric solid tumors: The promise of liquid biopsies. 

Abbou SD, Shulman D, DuBois SG, Crompton B
Journal Article: JCO precision oncology Year: 2019
Volume: 2019

Detection of Circulating Tumor DNA in Patients With Leiomyosarcoma With Progressive Disease. 

Hemming ML, Klega KS, Rhoades J, Ha G, Acker KE, Andersen JL, Thai E, Nag A, Thorner AR, Raut CP, George S, Crompton B
Journal Article: British journal of cancer Year: 2018
Issue: 5 Volume: 119 Page: 615-621

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. 

Shulman D, Klega K, Imamovic-Tuco A, Clapp A, Nag A, Thorner AR, Van Allen E, Ha G, Lessnick SL, Gorlick R, Janeway K, Leavey PJ, Mascarenhas L, London W, Vo KT, Stegmaier K, Hall D, Krailo MD, Barkauskas DA, DuBois SG, Crompton B
Journal Article: Molecular cancer therapeutics Year: 2018

Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma with SP-2509 engages the endoplasmic reticulum stress response. 

Pishas KI, Drenberg CD, Taslim C, Theisen ER, Johnson KM, Saund RS, Pop IL, Crompton B, Lawlor ER, Tirode F, Mora J, Delattre O, Beckerle MC, Callen DF, Sharma S, Lessnick SL
Journal Article: JCO precision oncology Year: 2018
Volume: 2018

Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid Tumors. 

Klega K, Imamovic-Tuco A, Ha G, Clapp AN, Meyer S, Ward A, Clinton C, Nag A, Van Allen E, Mullen E, DuBois SG, Janeway K, Meyerson M, Thorner AR, Crompton B

DFCI Protocol 17-104, Pediatric Solid Tumor Banking Protocol

Journal Article: PloS one Year: 2017
Issue: 12 Volume: 12 Page: e0188835

Blood collection in cell-stabilizing tubes does not impact germline DNA quality for pediatric patients. 

Wollison BM, Thai E, Mckinney A, Ward A, Clapp A, Clinton C, Nag A, Thorner AR, Gastier-Foster JM, Crompton B
Journal Article: Pediatric blood & cancer Year: 2016
Issue: 11 Volume: 63 Page: 1974-82

Patient/parent perspectives on genomic tumor profiling of pediatric solid tumors: The Individualized Cancer Therapy (iCat) experience. 

Marron J, DuBois SG, Glade Bender J, Kim A, Crompton B, Meyer SC, Janeway K, Mack J
Journal Article: Nature communications Year: 2016
Volume: 7 Page: 11987

Integrated genetic and pharmacologic interrogation of rare cancers. 

Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, Kryukov GV, Clemons PA, Tsherniak A, Vazquez F, Crompton B, Shamji AF, Rodriguez-Galindo C, Janeway K, Roberts C, Stegmaier K, van Hummelen P, Cima MJ, Langer RS, Garraway LA, Schreiber SL, Root DE, Hahn WC, Boehm JS
Journal Article: Cancer genetics Year: 2016
Issue: 5 Volume: 209 Page: 182-94

Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop. 

Hingorani P, Janeway K, Crompton B, Kadoch C, Mackall CL, Khan J, Shern JF, Schiffman J, Mirabello L, Savage SA, Ladanyi M, Meltzer P, Bult CJ, Adamson PC, Lupo PJ, Mody R, DuBois SG, Parsons DW, Khanna C, Lau C, Hawkins DS, Randall RL, Smith M, Sorensen PH, Plon SE, Skapek SX, Lessnick S, Gorlick R, Reed DR
Journal Article: JAMA oncology Year: 2016

Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study. 

Harris MH, DuBois SG, Glade Bender JL, Kim A, Crompton B, Parker E, Dumont IP, Hong AL, Guo D, Church A, Stegmaier K, Roberts C, Shusterman S, London W, MacConaill LE, Lindeman NI, Diller L, Rodriguez-Galindo C, Janeway K

DFCI Protocol 15-169, Multicenter Cohort Study to Evaluate Outcomes after Receipt of Targeted Therapy Matched to an Individualized Cancer Therapy Recommendations,

Journal Article: Oncotarget Year: 2015
Issue: 30 Volume: 6 Page: 30178-93

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma. 

Kennedy A, Vallurupalli M, Chen L, Crompton B, Cowley G, Vazquez F, Weir BA, Tsherniak A, Parasuraman S, Kim S, Alexe G, Stegmaier K
Journal Article: JIMD reports Year: 2015
Volume: 24 Page: 91-6

CSF 5-Methyltetrahydrofolate Serial Monitoring to Guide Treatment of Congenital Folate Malabsorption Due to Proton-Coupled Folate Transporter (PCFT) Deficiency. 

Torres A, Newton SA, Crompton B, Borzutzky A, Neufeld E, Notarangelo L, Berry G
Journal Article: The Journal of clinical investigation Year: 2014
Issue: 12 Volume: 124 Page: 5275-90

Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. 

Marques Howarth M, Simpson D, Ngok SP, Nieves B, Chen R, Siprashvili Z, Vaka D, Breese MR, Crompton B, Alexe G, Hawkins DS, Jacobson D, Brunner AL, West R, Mora J, Stegmaier K, Khavari P, Sweet-Cordero EA
Journal Article: Cancer discovery Year: 2014
Issue: 11 Volume: 4 Page: 1326-41

The genomic landscape of pediatric Ewing sarcoma. 

Crompton B, Stewart C, Taylor-Weiner A, Alexe G, Kurek KC, Calicchio ML, Kiezun A, Carter SL, Shukla SA, Mehta S, Thorner AR, de Torres C, Lavarino C, Suñol M, McKenna A, Sivachenko A, Cibulskis K, Lawrence MS, Stojanov P, Rosenberg M, Ambrogio L, Auclair D, Seepo S, Blumenstiel B, DeFelice M, Imaz-Rosshandler I, Schwarz-Cruz Celis A, Rivera MN, Rodriguez-Galindo C, Fleming MD, Golub T, Getz G, Mora J, Stegmaier K
Journal Article: Nature Year: 2013
Issue: 7457 Volume: 499 Page: 214-8

Mutational heterogeneity in cancer and the search for new cancer-associated genes. 

Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Lee RS, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts C, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub T, Gordenin DA, Sunyaev S, Lander ES, Getz G
Journal Article: Cancer research Year: 2013
Issue: 9 Volume: 73 Page: 2873-83

High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. 

Crompton B, Carlton AL, Thorner AR, Christie AL, Du J, Calicchio ML, Rivera MN, Fleming MD, Kohl NE, Kung AL, Stegmaier K
Journal Article: Clinical immunology (Orlando, Fla.) Year: 2009
Issue: 3 Volume: 133 Page: 287-94

Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter. 

Borzutzky A, Crompton B, Bergmann AK, Giliani S, Baxi S, Martin M, Neufeld E, Notarangelo L
Journal Article: Pediatric blood & cancer Year: 2006
Issue: 3 Volume: 47 Page: 255-9

Survival after recurrence of osteosarcoma: a 20-year experience at a single institution. 

Crompton B, Goldsby RE, Weinberg VK, Feren R, O'Donnell RJ, Ablin AR