The laboratory focuses on analysis of the function of members of the Rho GTPase family
The laboratory has demonstrated that Rac GTPases are key regulators of the engraftment and mobilization functions of hematopoietic stem cells.
The major interest of the Williams laboratory is the biology of hematopoietic stem cells. The work has focused on understanding the interaction of hematopoietic stem cells with the bone marrow and abnormalities of these interactions, which are associated with leukemia. These basic studies contribute to our translational research focus that utilizes hematopoietic stem cells as a target for gene therapy manipulations. We believe these studies will lead to the development of more effective therapies for patients.
In a new study presented in Washington, D.C., all but one of 17 boys with adrenoleukodystrophy (ALD) remained relatively healthy for up to 2 years after having an engineered virus deliver into their cells a gene to replenish a missing protein needed by the brain...Read More