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Active Grants and Sponsored Research

Sponsor Grant ID: 1U01TR001814-01 Project Date: September 15, 2016 - August 31, 2021
Sponsoring Organization: NIH/NCATS

Disseminating Curative Biological Therapies for Rare Pediatric Diseases

Description of Major Goals
This project seeks to develop a network of pediatric centers with unique expertise and experience in translation of gene therapies. Our overall goal is to support investigators across multiple CTSAs to more rapidly translate complex gene therapies to early phase investigator-initiated pediatric clinical trials suitable for transfer to industry.
Sponsor Grant ID: 1R01CA202756-01A1 Project Date: July 1, 2016 - June 30, 2021
Sponsoring Organization: NIH

Development of novel selective Rac inhibitors for refractory leukemias

Description of Major Goals
The goal of this project is to carry out orthogonal approaches to develop small molecule inhibitors of Rac for the treatment of refractory leukemias (in particular, MLL-rearranged and RAS-mutated).
Sponsor Grant ID: 2T32HL007574-34 Project Date: July 1, 1975 - June 30, 2020
Sponsoring Organization: National Heart, Lung And Blood Institute (NHLBI)

Pathophysiology of Human Blood Cells

Description of Major Goals
Goal of this program is to train physicians who will be the future academic leaders in pediatric Hematology/Oncology.
Sponsor Grant ID: 5U01HL117720-03 Project Date: August 15, 2013 - May 31, 2018
Sponsoring Organization: National Institutes Of Health (NIH)

Translational and clinical studies targeting γ-globin modulation

Description of Major Goals
The overarching goal is to utilize innovative scientific approaches to identify and put into clinical investigation new therapeutic modalities that modulate γ-globin expression.
Project Date: July 1, 2010 - September 30, 2017
Sponsoring Organization: Harvard Stem Cell Institute

HSCI FACS Core Facility Award

Description of Major Goals
This grant is to support a core facility that isolates normal and leukemia stem cells for investigators a Boston Children’s Hospital and the Harvard Stem Cell Institute.
Sponsor Grant ID: 5U01AI087628-05 Project Date: September 01, 2010 - August 31, 2017
Sponsoring Organization: National Institute Of Allergy And Infect Diseases (NIAID)

Gene Transfer for SCID-X1 using a self-inactivating gammaretroviral vector

Description of Major Goals
The aims of this study are to assess the safety of somatic gene transfer for SCID-X1 using the pSRS11.EFS.IL2RG.pre* vector, assess the efficacy of somatic gene transfer in specific lineages, and assess the impact on T and B cell reconstitution and clinical outcome. My role as co-PI is to serve as co-investigator on the clinical trial, assist in setting up and implementation of the trial, recruit subjects, and supervise endpoint analysis in my laboratory.
Sponsor Grant ID: 5R01DK062757 Project Date: April 01, 2002 - June 30, 2017
Sponsoring Organization: National Institute Diab & Digest & Kid Diseases (NIDDKD)

Rac proteins in hematopoietic cell survival and function

Description of Major Goals
The major goal of this project is to determine the role of Rac GTPase signaling in blood cell development and function.