Journal Article: The Journal of Clinical Investigation Year: 2016
Issue: 10 Volume: 126 Page: 3868-3878

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. 

Brendel C, Guda S, Renella R, Bauer D, Canver MC, Kim YJ, Heeney M, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory R, Williams D
Journal Article: Blood Year: 2016
Issue: 16 Volume: 127 Page: 1967-75

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. 

Reddy PN, Radu M, Xu K, Wood J, Harris CE, Chernoff J, Williams D
Journal Article: Nature Year: 2015
Issue: 7548 Volume: 520 Page: 549-52

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. 

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams D, Trumpp A, Milsom MD
Journal Article: Nature Genetics Year: 2015
Issue: 2 Volume: 47 Page: 180-5

Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. 

Zhang MY, Churpek JE, Keel SB, Walsh T, Lee M, Loeb KR, Gulsuner S, Pritchard CC, Sanchez-Bonilla M, Delrow JJ, Basom RS, Forouhar M, Gyurkocza B, Schwartz BS, Neistadt B, Marquez R, Mariani CJ, Coats SA, Hofmann I, Lindsley RC, Williams D, Abkowitz JL, Horwitz MS, King MC, Godley LA, Shimamura A
Journal Article: The Journal of Clinical Investigation Year: 2012
Issue: 9 Volume: 122 Page: 3239-47

Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections. 

Crequer A, Troeger A, Patin E, Ma CS, Picard C, Pedergnana V, Fieschi C, Lim A, Abhyankar A, Gineau L, Mueller-Fleckenstein I, Schmidt M, Taieb A, Krueger J, Abel L, Tangye SG, Orth G, Williams D, Casanova JL, Jouanguy E
Journal Article: Cancer Cell Year: 2007
Issue: 5 Volume: 12 Page: 467-78

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. 

Thomas EK, Cancelas JA, Chae HD, Cox AD, Keller PJ, Perrotti D, Neviani P, Druker BJ, Setchell KD, Zheng Y, Harris CE, Williams D
Journal Article: Nature Medicine Year: 2005
Issue: 8 Volume: 11 Page: 886-91

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. 

Cancelas JA, Lee AW, Prabhakar R, Stringer KF, Zheng Y, Williams D
Journal Article: Nature Immunology Year: 2004
Issue: 7 Volume: 5 Page: 744-51

Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. 

Filippi MD, Harris CE, Meller J, Gu Y, Zheng Y, Williams D
Journal Article: Science Year: 2003
Issue: 5644 Volume: 302 Page: 445-9

Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. 

Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, Jasti AC, Harris CE, Lee AW, Prabhakar R, Atkinson SJ, Kwiatkowski DJ, Williams D
Journal Article: Blood Year: 2000
Issue: 5 Volume: 96 Page: 1646-54

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. 

Williams D, Tao W, Yang F, Kim C, Gu Y, Mansfield P, Levine JE, Petryniak B, Derrow CW, Harris C, Jia B, Zheng Y, Ambruso DR, Lowe JB, Atkinson SJ, Dinauer MC, Boxer L
Journal Article: Immunity Year: 1999
Issue: 2 Volume: 10 Page: 183-96

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. 

Roberts A, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA
Journal Article: The Journal of Clinical Investigation Year: 1998
Issue: 5 Volume: 102 Page: 1051-61

VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin. 

van der Loo JC, Xiao X, McMillin D, Hashino K, Kato I, Williams DA
Journal Article: Nature Medicine Year: 1996
Issue: 8 Volume: 2 Page: 876-82

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. 

Hanenberg H, Xiao XL, Dilloo D, Hashino K, Kato I, Williams DA
Journal Article: Blood Year: 1996
Issue: 3 Volume: 88 Page: 855-62

Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: evidence of direct viral binding to chymotryptic carboxy-terminal fragments. 

Moritz T, Dutt P, Xiao X, Carstanjen D, Vik T, Hanenberg H, Williams DA
Journal Article: Blood Year: 1991
Issue: 8 Volume: 77 Page: 1723-33

Stromal cell-associated hematopoiesis: immortalization and characterization of a primate bone marrow-derived stromal cell line. 

Paul SR, Yang YC, Donahue RE, Goldring S, Williams DA
Journal Article: Cell Year: 1990
Issue: 1 Volume: 63 Page: 213-24

Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. 

Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, Murdock DC
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 1990
Issue: 19 Volume: 87 Page: 7512-6

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. 

Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara, Jr RM, Leary AC, Sibley B, Clark SC, Williams DA
Journal Article: Nature Year: 1984
Issue: 5977 Volume: 310 Page: 476-80

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. 

Williams DA, Lemischka IR, Nathan D, Mulligan RC