Our Laboratories

Bahl Lab

We are leveraging cutting-edge protein engineering methods to create genetically-encodable macromolecules with novel function. The combination of computational design and directed evolution is unlocking new proteins with capabilities never before…

Bauer Lab

The laboratory studies the genetic determinants of blood cell ontogeny and disease. The blood system recapitulates fundamental biologic activities, such as renewal/differentiation, regeneration/homeostasis, and development/aging. We use molecular genetic, biochemical,…

Luca Biasco Lab

Using barcoding for the in vivo clonal tracking of genetically engineered cells and retroviral scanning for the characterization of cellular genetic and nuclear identity Our laboratory seeks to elucidate the…

Carla Kim Lab

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic…

Croker Lab

The laboratory studies immunomodulatory forms of cell death including pyroptosis and necroptosis. The role of these novel cell death pathways is investigated during hematopoietic stress induced by infection, chemotherapy, transplantation…

Daley Lab

Our laboratory seeks a better understanding of the biology, pathology, and clinical utility of hematopoietic and pluripotent stem cells and of the role of various tissue stem cells in development…

Knoechel Lab

Our research efforts focus on identifying epigenetic dependencies in pediatric tumors with a particular focus on high risk pediatric leukemias and sarcomas. Defects in chromatin and aberrant epigenetic regulation and…

Center for Platelet Research Studies

The Center for Platelet Research Studies is an internationally recognized multidisciplinary center for the study of platelet function by state-of-the-art methods. The Center undertakes basic, translational, and clinical research, including…

Orkin Lab

The Orkin laboratory focuses on stem cell biology, particularly the development and function of the blood system, the relationship between cancer and stem cells, and the mechanisms responsible for self-renewal…

Sankaran Laboratory

The Sankaran laboratory uses human genetic studies to gain insight into normal hematopoiesis and how this process is perturbed in disease. Our studies are relevant to numerous blood diseases, including…

Shimamura Lab

The broad interest of the Shimamura lab is the genetic and molecular mechanisms regulating hematopoiesis and clonal evolution to MDS and leukemia. The Shimamura lab studies inherited bone marrow failure…

The Alejandro Gutierrez Lab

Our laboratory’s primary interest lies in unraveling the molecular pathogenesis of human cancer, with a focus on discovery of novel therapeutic targets in chemoresistant human cancers. Our approach combines analysis…

The Bandopadhayay Lab

The Bandopadhayay Lab at Dana-Farber Cancer Institute focuses on: Identifying genomic and epigenetic drivers of pediatric brain tumors, characterizing resistance mechanisms of pediatric brain tumors, and developing more effective treatments…

Williams Laboratory

Walensky Laboratory

The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. In particular, the lab’s studies emphasize the chemical, structural, and cell biology of the…

Weinstock Laboratory

The Weinstock Laboratory uses a range of approaches at the intersection of genetics, DNA repair, and mouse modeling to address the ontogeny, pathogenesis, and therapeutic targeting of lymphoid neoplasms.