Active Grants and Sponsored Research

The long-term goal of this Outstanding Investigator Award application is to experimentally dissect the specific DNA sequences, transcription factors, transcriptional adaptors and mediators, and epigenetic readers, writers and erasers that are required to form and sustain aberrant transcriptional enhancers capable of driving high levels of key oncogene expression in human cancer cells.

The major goals of this project are to define the regulatory mechanisms of the LMO1 gene and its role in the initiation of neuroblastoma, and to elucidate the mechanisms by which LMO1 contributes to maintenance of the malignant phenotype in neuroblastoma.