Active Grants and Sponsored Research
Sponsoring Organization: National Institutes of Health (NIH)
Mechanisms and Vulnerabilities of Aberrant Transcriptional Enhancers in Cancer
Description of Major GoalsThe long-term goal of this Outstanding Investigator Award application is to experimentally dissect the specific DNA sequences, transcription factors, transcriptional adaptors and mediators, and epigenetic readers, writers and erasers that are required to form and sustain aberrant transcriptional enhancers capable of driving high levels of key oncogene expression in human cancer cells.
Sponsoring Organization: National Institutes of Health (NIH)
Role of LMO1 in Neuroblastoma Initiation and Maintenance
Description of Major GoalsThe major goals of this project are to define the regulatory mechanisms of the LMO1 gene and its role in the initiation of neuroblastoma, and to elucidate the mechanisms by which LMO1 contributes to maintenance of the malignant phenotype in neuroblastoma.