MENU

Publications

Journal Article: The Journal of experimental medicine Year: 2018
Issue: 7 Volume: 215 Page: 1929-1945

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. 

Mansour M, He S, Li Z, Lobbardi R, Abraham BJ, Hug C, Rahman S, Leon TE, Kuang YY, Zimmerman MW, Blonquist T, Gjini E, Gutierrez A, Tang Q, Garcia-Perez L, Pike-Overzet K, Anders L, Berezovskaya A, Zhou Y, Zon L, Neuberg D, Fielding AK, Staal FJT , Langenau DM, Sanda T, Young RA, Look T
Journal Article: Cancer discovery Year: 2018
Issue: 3 Volume: 8 Page: 320-335

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. 

Zimmerman MW, Liu Y, He S, Durbin A, Abraham BJ, Easton J, Shao Y, Xu B, Zhu S, Zhang X, Li Z, Weichert-Leahey N, Young RA, Zhang J, Look T
Journal Article: Leukemia Year: 2017
Issue: 10 Volume: 31 Page: 2057-2064

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. 

Li Z, Abraham BJ, Berezovskaya A, Farah N, Liu Y, Leon T, Fielding A, Tan SH, Sanda T, Weintraub AS, Li B, Shen S, Zhang J, Mansour M, Young RA, Look T
Journal Article: Cancer cell Year: 2017
Issue: 3 Volume: 32 Page: 310-323.e5

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. 

Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, Tao T, He S, Wood AC, Oldridge D, Ung CY, van Ree JH, Khan A, Salazar BM, da Lummertz Rocha E, Zimmerman MW, Guo F, Cao H, Hou X, Weroha SJ, Perez-Atayde AR, Neuberg DS, Meves A, McNiven MA, van Deursen JM, Li H, Maris JM, Look T
Journal Article: Oncogene Year: 2017
Issue: 27 Volume: 36 Page: 3852-3867

The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. 

Tao T, Sondalle SB, Shi H, Zhu S, Perez-Atayde AR, Peng J, Baserga SJ, Look T
Journal Article: British journal of haematology Year: 2017
Issue: 2 Volume: 177 Page: 271-282

Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia. 

Akahane K, Li Z, Etchin J, Berezovskaya A, Gjini E, Masse CE, Miao W, Rocnik J, Kapeller R, Greenwood JR, Tiv H, Sanda T, Weinstock DM, Look T
Journal Article: Cell reports Year: 2017
Issue: 12 Volume: 18 Page: 2932-2942

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation. 

Zhang X, Dong Z, Zhang C, Ung CY, He S, Tao T, Oliveira AM, Meves A, Ji B, Look T, Li H, Neel BG, Zhu S
Journal Article: Oncogene Year: 2017
Issue: 8 Volume: 36 Page: 1058-1068

Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors. 

Ki DH, He S, Rodig S, Look T
Journal Article: Nature communications Year: 2017
Volume: 8 Page: 14385

Small genomic insertions form enhancers that misregulate oncogenes. 

Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look T, Mansour M, Young RA
Journal Article: Leukemia Year: 2017
Issue: 1 Volume: 31 Page: 143-150

KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. 

Etchin J, Berezovskaya A, Conway AS, Galinsky IA, Stone RM, Baloglu E, Senapedis W, Landesman Y, Kauffman M, Shacham S, Wang JC, Look T
Journal Article: Methods in cell biology Year: 2017
Volume: 138 Page: 563-592

Zebrafish models of leukemia. 

He S, Jing CB, Look T
Journal Article: Leukemia Year: 2016

KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. 

Etchin J, Berezovskaya A, Conway AS, Galinsky IA, Stone RM, Baloglu E, Senapedis W, Landesman Y, Kauffman M, Shacham S, Wang J, Look T
Journal Article: eLife Year: 2016
Volume: 5

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. 

He S, Mansour M, Zimmerman MW, Ki DH, Layden HM, Akahane K, Gjini E, de Groh ED, Perez-Atayde AR, Zhu S, Epstein JA, Look T
Journal Article: Leukemia Year: 2016
Issue: 1 Volume: 30 Page: 190-9

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice. 

Etchin J, Montero J, Berezovskaya A, Le BT, Kentsis A, Christie AL, Conway AS, Chen WC, Reed C, Mansour M, Ng CE, Adamia S, Rodig SJ, Galinsky IA, Stone RM, Klebanov B, Landesman Y, Kauffman M, Shacham S, Kung AL, Wang JC, Letai A, Look T
Journal Article: Leukemia Year: 2016
Issue: 1 Volume: 30 Page: 219-28

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. 

Akahane K, Sanda T, Mansour M, Radimerski T, DeAngelo DJ, Weinstock DM, Look T
Journal Article: Advances in experimental medicine and biology Year: 2016
Volume: 916 Page: 495-530

Malignant Peripheral Nerve Sheath Tumors. 

Durbin A, Ki DH, He S, Look T
Journal Article: Methods in cell biology Year: 2016
Volume: 134 Page: 97-138

Studying the peripheral sympathetic nervous system and neuroblastoma in zebrafish. 

Morrison MA, Zimmerman MW, Look T, Stewart RA
Journal Article: Molecular and cellular biology Year: 2015
Issue: 5 Volume: 35 Page: 789-804

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. 

Gjini E, Mansour M, Sander JD, Moritz N, Nguyen AT, Kesarsing M, Gans E, He S, Chen S, Ko M, Kuang YY, Yang S, Zhou Y, Rodig S, Zon L, Joung JK, Rao A, Look T
Journal Article: British journal of haematology Year: 2015
Issue: 2 Volume: 168 Page: 230-8

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. 

Mansour M, Reed C, Eisenberg AR, Tseng JC, Twizere JC, Daakour S, Yoda A, Rodig SJ, Tal N, Shochat C, Berezovskaya A, DeAngelo DJ, Sallan S, Weinstock DM, Izraeli S, Kung AL, Kentsis A, Look AT
Journal Article: Science (New York, N.Y.) Year: 2014
Issue: 6215 Volume: 346 Page: 1373-7

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. 

Mansour M, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, Etchin J, Lawton L, Sallan S, Silverman L, Loh ML, Hunger SP, Sanda T, Young RA, Look T
Journal Article: Nature cell biology Year: 2014
Issue: 11 Volume: 16 Page: 1080-91

Cyclin C is a haploinsufficient tumour suppressor. 

Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour M, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P
Journal Article: British journal of haematology Year: 2014
Issue: 4 Volume: 167 Page: 524-8

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. 

Narla A, Payne EM, Abayasekara N, Hurst SN, Raiser DM, Look AT, Berliner N, Ebert BL, Khanna-Gupta A
Journal Article: Gastroenterology Year: 2014
Issue: 4 Volume: 147 Page: 882-892.e8

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells. 

Barceló C, Etchin J, Mansour M, Sanda T, Ginesta MM, Sanchez-Arévalo Lobo VJ, Real FX, Capellà G, Estanyol JM, Jaumot M, Look AT, Agell N
Journal Article: Leukemia Year: 2014
Issue: 9 Volume: 28 Page: 1819-27

Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. 

Reynolds C, Roderick JE, LaBelle JL, Bird G, Mathieu R, Bodaar K, Colon D, Pyati U, Stevenson KE, Qi J, Harris M, Silverman L, Sallan S, Bradner JE, Neuberg DS, Look AT, Walensky L, Kelliher MA, Gutierrez A
Journal Article: British journal of haematology Year: 2014
Issue: 1 Volume: 166 Page: 84-90

Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. 

Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT
Other: Leukemia Year: 2014
Issue: 5 Volume: 28 Page: 1145-8

BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines. 

Anderson NM, Harrold I, Mansour M, Sanda T, McKeown M, Nagykary N, Bradner JE, Lan Zhang G, Look T, Feng H
Journal Article: Blood Year: 2014
Issue: 16 Volume: 123 Page: 2451-9

Notch signaling: switching an oncogene to a tumor suppressor. 

Lobry C, Oh P, Mansour M, Look T, Aifantis I
Journal Article: The Journal of clinical investigation Year: 2014
Issue: 2 Volume: 124 Page: 644-55

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. 

Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look T, Aster JC
Journal Article: The Journal of experimental medicine Year: 2013
Issue: 8 Volume: 210 Page: 1545-57

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. 

Mansour M, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look T
Journal Article: eLife Year: 2013
Volume: 2 Page: e00825

MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy. 

Heinrichs S, Conover LF, Bueso-Ramos CE, Kilpivaara O, Stevenson K, Neuberg D, Loh ML, Wu WS, Rodig SJ, Garcia-Manero G, Kantarjian HM, Look T
Journal Article: Cancer discovery Year: 2013
Issue: 5 Volume: 3 Page: 564-77

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. 

Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman A, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look T
Journal Article: Leukemia Year: 2013
Issue: 1 Volume: 27 Page: 66-74

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. 

Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour M, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, Look T
Journal Article: Disease models & mechanisms Year: 2012
Issue: 6 Volume: 5 Page: 881-94

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. 

Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look T
Journal Article: Cell stem cell Year: 2012
Issue: 3 Volume: 11 Page: 281-2

Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis. 

Kentsis A, Look T
Journal Article: Cancer cell Year: 2012
Issue: 2 Volume: 22 Page: 209-21

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. 

Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look T
Journal Article: Nature medicine Year: 2012
Issue: 7 Volume: 18 Page: 1118-22

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. 

Kentsis A, Reed C, Rice KL, Sanda T, Rodig SJ, Tholouli E, Christie A, Valk PJ, Delwel R, Ngo V, Kutok JL, Dahlberg SE, Moreau LA, Byers RJ, Christensen JG, Vande Woude G, Licht JD, Kung AL, Staudt LM, Look T
Journal Article: Cancer cell Year: 2012
Issue: 3 Volume: 21 Page: 362-73

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. 

Zhu S, Lee JS, Guo F, Shin J, Perez-Atayde AR, Kutok JL, Rodig SJ, Neuberg DS, Helman D, Feng H, Stewart RA, Wang W, George R, Kanki JP, Look T
Journal Article: PloS one Year: 2012
Issue: 6 Volume: 7 Page: e39725

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. 

Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look T, Jamieson CH
Journal Article: Cancer cell Year: 2011
Issue: 5 Volume: 20 Page: 559-61

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma. 

Mansour M, Look T
Journal Article: Blood Year: 2011
Issue: 15 Volume: 118 Page: 4169-73

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. 

Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman L, Winter SS, Hunger SP, Sallan S, Zha S, Alt F, Downing JR, Mullighan CG, Look T
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2011
Issue: 39 Volume: 108 Page: 16386-91

Aberrant AKT activation drives well-differentiated liposarcoma. 

Gutierrez A, Snyder EL, Marino-Enriquez A, Zhang YX, Sioletic S, Kozakewich E, Grebliunaite R, Ou WB, Sicinska E, Raut CP, Demetri GD, Perez-Atayde AR, Wagner AJ, Fletcher JA, Fletcher CD, Look T
Journal Article: Developmental cell Year: 2011
Issue: 3 Volume: 21 Page: 492-505

p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis. 

Pyati UJ, Gjini E, Carbonneau S, Lee JS, Guo F, Jette CA, Kelsell DP, Look T
Journal Article: The Journal of experimental medicine Year: 2011
Issue: 8 Volume: 208 Page: 1595-603

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. 

Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F, Payne E, Mansour M, Dahlberg SE, Neuberg DS, den Hertog J, Prochownik EV, Testa JR, Harris M, Kanki JP, Look T
Journal Article: Blood Year: 2011
Issue: 4 Volume: 118 Page: 903-15

Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML. 

Payne EM, Bolli N, Rhodes J, Abdel-Wahab OI, Levine R, Hedvat CV, Stone R, Khanna-Gupta A, Sun H, Kanki JP, Gazda H, Beggs A, Cotter FE, Look T
Journal Article: Blood Year: 2011
Issue: 15 Volume: 117 Page: 3996-4007

cpsf1 is required for definitive HSC survival in zebrafish. 

Bolli N, Payne EM, Rhodes J, Gjini E, Johnston AB, Guo F, Lee JS, Stewart RA, Kanki JP, Chen AT, Zhou Y, Zon L, Look T
Journal Article: Leukemia Year: 2011
Issue: 3 Volume: 25 Page: 506-14

Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb. 

Grabher C, Payne EM, Johnston AB, Bolli N, Lechman E, Dick JE, Kanki JP, Look T
Journal Article: Methods in cell biology Year: 2011
Volume: 105 Page: 309-37

Zebrafish as a model for the study of human cancer. 

Etchin J, Kanki JP, Look T
Journal Article: Human molecular genetics Year: 2010
Issue: 23 Volume: 19 Page: 4643-53

Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. 

Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look T
Journal Article: Cancer cell Year: 2010
Issue: 4 Volume: 18 Page: 353-66

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. 

Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon L, Traver D, Fleming MD, Kanki JP, Look T
Journal Article: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Year: 2010
Issue: 24 Volume: 28 Page: 3816-23

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. 

Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman L, Chin L, Hunger SP, Sallan S, Look T
Journal Article: The Journal of experimental medicine Year: 2010
Issue: 7 Volume: 207 Page: 1369-80

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. 

Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look T, Alt F