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Journal Article: Cell reports Year: 2016
Issue: 12 Volume: 16 Page: 3181-94

Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. 

Luc S, Huang J, McEldoon JL, Somuncular E, Li D, Rhodes C, Mamoor S, Hou S, Xu J, Orkin SH
Journal Article: Cancer discovery Year: 2016

Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2. 

Xie H, Peng C, Huang J, Li BE, Kim W, Smith EC, Fujiwara Y, Qi J, Cheloni G, Das PP, Nguyen M, Li S, Bradner JE, Orkin SH
Journal Article: Developmental cell Year: 2016
Issue: 1 Volume: 36 Page: 9-23

Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. 

Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon L, Yuan GC, Orkin SH, Xu J
Journal Article: Nature Year: 2015

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. 

Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer D
Journal Article: Molecular cell Year: 2015
Issue: 2 Volume: 57 Page: 304-16

Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. 

Xu J, Shao Z, Li D, Orkin SH, Kim W, Huang J, Taylor JE, Pinello L, Glass K, Jaffe JD, Yuan GC, Orkin SH
Journal Article: J. Biol. Chem. Volume: 289 Page: 21312-21324

Efficient genomic deletions in mammalian cells using CRISPR/Cas9

Canver M, Bauer D, Paw B, A, ,
Journal Article: Genes & development Year: 2014

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. 

Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, Speck NA
Journal Article: The Journal of experimental medicine Year: 2014
Issue: 11 Volume: 211 Page: 2213-30

Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. 

Lundberg P, Takizawa H, Kubovcakova L, Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC
Journal Article: The Journal of clinical investigation Year: 2014
Issue: 10 Volume: 124 Page: 4294-304

TMEM14C is required for erythroid mitochondrial heme metabolism. 

Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer D, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C, Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger T, DiMauro S, Orkin SH, Cantor A, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL, Paw B
Journal Article: The Journal of biological chemistry Year: 2014
Issue: 31 Volume: 289 Page: 21312-24

Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. 

Canver MC, Bauer D, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw B, Orkin SH
Journal Article: Blood Year: 2014
Issue: 20 Volume: 123 Page: 3175-84

Corepressor Rcor1 is essential for murine erythropoiesis. 

Yao H, Goldman DC, Nechiporuk T, Kawane S, McWeeney SK, Tyner JW, Fan G, Kerenyi MA, Orkin SH, Fleming WH, Mandel G
Journal Article: The Journal of experimental medicine Year: 2014
Issue: 5 Volume: 211 Page: 909-27

Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. 

Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H
Journal Article: Cell Year: 2014
Issue: 3 Volume: 157 Page: 549-64

Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. 

Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi D
Journal Article: Leukemia Year: 2014
Issue: 3 Volume: 28 Page: 577-88

Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy. 

Stankov MV, El Khatib M, Kumar Thakur B, Heitmann K, Panayotova-Dimitrova D, Schoening J, Bourquin JP, Schweitzer N, Leverkus M, Welte K, Reinhardt D, Li Z, Orkin SH, Behrens GM, Klusmann JH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2014
Issue: 3 Volume: 111 Page: E344-53

Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. 

Pinello L, Xu J, Orkin SH, Yuan GC
Journal Article: Molecular cell Year: 2014
Issue: 1 Volume: 53 Page: 32-48

Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. 

Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, Daley G, Hochedlinger K, Kim J, Orkin SH
Journal Article: Cell stem cell Year: 2014
Issue: 1 Volume: 14 Page: 68-80

Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. 

Xie H, Xu J, Hsu JH, Nguyen M, Fujiwara Y, Peng C, Orkin SH
Journal Article: Cell stem cell Year: 2014
Issue: 1 Volume: 14 Page: 68-80

Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. 

Xie H, Xu J, Hsu JH, Nguyen M, Fujiwara Y, Peng C, Orkin SH
Journal Article: Developmental cell Year: 2013
Issue: 6 Volume: 27 Page: 607-20

Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. 

Elagib KE, Rubinstein JD, Delehanty LL, Ngoh VS, Greer PA, Li S, Lee J, Li Z, Orkin SH, Mihaylov IS, Goldfarb AN
Journal Article: Science (New York, N.Y.) Year: 2013
Issue: 6155 Volume: 342 Page: 253-7

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. 

Bauer D, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH
Journal Article: Science (New York, N.Y.) Year: 2013
Issue: 6155 Volume: 342 Page: 253-7

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. 

Bauer D, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH
Journal Article: Cell stem cell Year: 2013
Issue: 4 Volume: 13 Page: 492-505

Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. 

Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH
Journal Article: Cell stem cell Year: 2013
Issue: 4 Volume: 13 Page: 492-505

Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. 

Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH
Journal Article: Nature chemical biology Year: 2013
Issue: 10 Volume: 9 Page: 643-50

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. 

Kim W, Bird G, Neff T, Guo G, Kerenyi MA, Walensky L, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2013
Issue: 29 Volume: 110 Page: 11670-1

Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells. 

Luc S, Orkin SH
Journal Article: eLife Year: 2013
Volume: 2 Page: e00633

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. 

Kerenyi MA, Shao Z, Hsu YJ, Guo G, Luc S, O'Brien K, Fujiwara Y, Peng C, Nguyen M, Orkin SH
Journal Article: Current opinion in genetics & development Year: 2013
Issue: 3 Volume: 23 Page: 339-44

Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis. 

Sankaran V, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2013
Issue: 16 Volume: 110 Page: 6518-23

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. 

Xu J, Bauer D, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH
Journal Article: Genes & development Year: 2013
Issue: 6 Volume: 27 Page: 683-98

ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. 

Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, Li Z
Journal Article: Molecular cell Year: 2013
Issue: 5 Volume: 49 Page: 934-46

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. 

Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG
Journal Article: Developmental biology Year: 2013
Issue: 2 Volume: 373 Page: 422-30

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. 

Bai X, Trowbridge JJ, Riley E, Lee J, DiBiase A, Kaartinen VM, Orkin SH, Zon L
Journal Article: Cold Spring Harbor perspectives in medicine Year: 2013
Issue: 1 Volume: 3 Page: a011643

The switch from fetal to adult hemoglobin. 

Sankaran V, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2012
Issue: 43 Volume: 109 Page: 17567-72

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. 

Maclean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley G, Orkin SH
Journal Article: Developmental cell Year: 2012
Issue: 4 Volume: 23 Page: 796-811

Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. 

Xu J, Shao Z, Glass K, Bauer D, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HK, Yuan GC, Orkin SH
Journal Article: Blood Year: 2012
Issue: 15 Volume: 120 Page: 2945-53

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders. 

Bauer D, Kamran SC, Orkin SH
Journal Article: Genes & development Year: 2012
Issue: 18 Volume: 26 Page: 2075-87

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. 

Sankaran V, Ludwig LS, Sicinska E, Xu J, Bauer D, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF
Journal Article: Cell Year: 2012
Issue: 3 Volume: 150 Page: 590-605

Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. 

Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK
Journal Article: Molecular and cellular biology Year: 2012
Issue: 16 Volume: 32 Page: 3281-92

The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. 

Funnell AP, Norton LJ, Mak KS, Burdach J, Artuz CM, Twine NA, Wilkins MR, Power CA, Hung TT, Perdomo J, Koh P, Bell-Anderson KS, Orkin SH, Fraser ST, Perkins AC, Pearson RC, Crossley M
Journal Article: The Journal of clinical investigation Year: 2012
Issue: 7 Volume: 122 Page: 2439-43

Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. 

Sankaran V, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs A, Sieff C, Orkin SH, Nathan D, Lander ES, Gazda H
Journal Article: Oncogene Year: 2012
Issue: 18 Volume: 31 Page: 2270-82

Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. 

Basu-Roy U, Seo E, Ramanathapuram L, Rapp TB, Perry JA, Orkin SH, Mansukhani A, Basilico C
Journal Article: Circulation Year: 2012
Issue: 12 Volume: 125 Page: 1520-32

MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. 

Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, Cottrill KA, Shaik RS, Waxman AB, Zhang Y, Maron BA, Hartner JC, Fujiwara Y, Orkin SH, Haley KJ, Barabási AL, Loscalzo J, Chan SY
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2012
Issue: 13 Volume: 109 Page: 5028-33

Polycomb repressive complex 2 is required for MLL-AF9 leukemia. 

Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA
Journal Article: Genome biology Year: 2012
Issue: 3 Volume: 13 Page: R16

MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. 

Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ
Journal Article: Science translational medicine Year: 2012
Issue: 124 Volume: 4 Page: 124ra29

A human stem cell model of early Alzheimer's disease pathology in Down syndrome. 

Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ
Journal Article: Genes & development Year: 2012
Issue: 4 Volume: 26 Page: 344-9

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. 

Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH
Journal Article: Science translational medicine Year: 2012
Issue: 121 Volume: 4 Page: 121ra18

MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. 

Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, MacKenna DA, Orkin SH, Duffield JS
Journal Article: Circulation research Year: 2012
Issue: 3 Volume: 110 Page: 406-15

Polycomb repressive complex 2 regulates normal development of the mouse heart. 

He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley G, Kong S, Orkin SH, Seidman CE, Seidman JG, Pu WT
Journal Article: Genes & development Year: 2012
Issue: 1 Volume: 26 Page: 37-42

PRC2 directly methylates GATA4 and represses its transcriptional activity. 

He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT
Journal Article: Nature genetics Year: 2011
Issue: 1 Volume: 44 Page: 13-4

Dnmt3a silences hematopoietic stem cell self-renewal. 

Trowbridge JJ, Orkin SH
Journal Article: Genome medicine Year: 2011
Issue: 11 Volume: 3 Page: 75

Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. 

Kim J, Orkin SH
Journal Article: Science (New York, N.Y.) Year: 2011
Issue: 6058 Volume: 334 Page: 993-6

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. 

Xu J, Peng C, Sankaran V, Shao Z, Esrick E, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH
Journal Article: Stem cells (Dayton, Ohio) Year: 2011
Issue: 11 Volume: 29 Page: 1705-16

Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. 

Fidalgo M, Shekar PC, Ang YS, Fujiwara Y, Orkin SH, Wang J
Journal Article: Journal of immunology (Baltimore, Md. : 1950) Year: 2011
Issue: 6 Volume: 187 Page: 3362-73

MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. 

Lu TX, Hartner J, Lim EJ, Fabry V, Mingler MK, Cole ET, Orkin SH, Aronow BJ, Rothenberg ME
Journal Article: The New England journal of medicine Year: 2011
Issue: 9 Volume: 365 Page: 807-14

A functional element necessary for fetal hemoglobin silencing. 

Sankaran V, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2011
Issue: 33 Volume: 108 Page: 13379-86

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. 

Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin, Jr WG, Yan Q
Journal Article: Cell Year: 2011
Issue: 6 Volume: 145 Page: 835-50

Chromatin connections to pluripotency and cellular reprogramming. 

Orkin SH, Hochedlinger K
Journal Article: Genome medicine Year: 2011
Issue: 6 Volume: 3 Page: 34

Genome Medicine: stem cells, genomics and translational research. 

Orkin SH
Journal Article: Blood Year: 2011
Issue: 18 Volume: 117 Page: 4769-72

Context-dependent function of "GATA switch" sites in vivo. 

Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH
Journal Article: The EMBO journal Year: 2011
Issue: 6 Volume: 30 Page: 983-5

The erythroid/myeloid lineage fate paradigm takes a new player. 

Xu J, Orkin SH
Journal Article: Blood Year: 2011
Issue: 10 Volume: 117 Page: 2817-26

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. 

Wilber A, Hargrove PW, Kim YS, Riberdy JM, Sankaran V, Papanikolaou E, Georgomanoli M, Anagnou NP, Orkin SH, Nienhuis AW, Persons DA
Journal Article: Cell stem cell Year: 2011
Issue: 2 Volume: 8 Page: 200-13

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. 

Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley G, Rao A
Journal Article: Current opinion in pediatrics Year: 2011
Issue: 1 Volume: 23 Page: 1-8

Update on fetal hemoglobin gene regulation in hemoglobinopathies. 

Bauer D, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2011
Issue: 4 Volume: 108 Page: 1519-24

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. 

Sankaran V, Menne TF, Šćepanović D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF
Journal Article: Nature genetics Year: 2010
Issue: 12 Volume: 42 Page: 1049-51

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. 

Galarneau G, Palmer CD, Sankaran V, Orkin SH, Hirschhorn J, Lettre G
Journal Article: Annals of the New York Academy of Sciences Year: 2010
Volume: 1214 Page: 47-56

Modifier genes in Mendelian disorders: the example of hemoglobin disorders. 

Sankaran V, Lettre G, Orkin SH, Hirschhorn J
Journal Article: The Journal of experimental medicine Year: 2010
Issue: 12 Volume: 207 Page: 2537-41

Networking erythropoiesis. 

Kerenyi MA, Orkin SH
Journal Article: Molecular and cellular biology Year: 2010
Issue: 22 Volume: 30 Page: 5364-80

Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. 

Rao S, Zhen S, Roumiantsev S, McDonald LT, Yuan GC, Orkin SH
Journal Article: Cancer cell Year: 2010
Issue: 4 Volume: 18 Page: 316-28

Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. 

Wilson B, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts C
Journal Article: Cell Year: 2010
Issue: 2 Volume: 143 Page: 313-24

A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. 

Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim C, Cantor A, Orkin SH
Journal Article: American journal of hematology Year: 2010
Issue: 10 Volume: 85 Page: 793-4

Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. 

Williams D, Porter ES, Lux, 4th SE, Grier H, Mack J, Orkin SH
Journal Article: Nature Year: 2010
Issue: 7313 Volume: 467 Page: 285-90

Epigenetic memory in induced pluripotent stem cells. 

Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley G
Journal Article: PLoS genetics Year: 2010
Issue: 9 Volume: 6 Page: e1001103

A single cis element maintains repression of the key developmental regulator Gata2. 

Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH
Journal Article: The Journal of biological chemistry Year: 2010
Issue: 36 Volume: 285 Page: 28064-75

Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). 

Snow JW, Kim J, Currie CR, Xu J, Orkin SH
Journal Article: Genes & development Year: 2010
Issue: 15 Volume: 24 Page: 1659-72

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. 

Klusmann JH, Godinho FJ, Heitmann K, Maroz A, Koch ML, Reinhardt D, Orkin SH, Li Z
Journal Article: Annals of the New York Academy of Sciences Year: 2010
Volume: 1202 Page: 64-8

Transcriptional silencing of fetal hemoglobin by BCL11A. 

Sankaran V, Xu J, Orkin SH
Journal Article: Science (New York, N.Y.) Year: 2010
Issue: 5989 Volume: 329 Page: 291-2

Medicine. Sickle cell disease at 100 years. 

Orkin SH, Higgs DR
Journal Article: Cell Year: 2010
Issue: 1 Volume: 142 Page: 133-43

TIF1gamma controls erythroid cell fate by regulating transcription elongation. 

Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor A, Orkin SH, Zon L
Journal Article: Genes & development Year: 2010
Issue: 8 Volume: 24 Page: 783-98

Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. 

Xu J, Sankaran V, Ni M, Menne TF, Puram RV, Kim W, Orkin SH
Journal Article: Blood Year: 2010
Issue: 14 Volume: 115 Page: 2928-37

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. 

Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL
Journal Article: British journal of haematology Year: 2010
Issue: 2 Volume: 149 Page: 181-94

Advances in the understanding of haemoglobin switching. 

Sankaran V, Xu J, Orkin SH
Journal Article: Epigenetics : official journal of the DNA Methylation Society Year: 2010
Issue: 3 Volume: 5 Page: 189-93

DNA methylation in adult stem cells: new insights into self-renewal. 

Trowbridge JJ, Orkin SH
Journal Article: Genes & development Year: 2010
Issue: 5 Volume: 24 Page: 478-90

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. 

Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D
Other: Nature biotechnology Year: 2010
Issue: 2 Volume: 28 Page: 146-7

Systematic tracking of cell fate changes. 

Kim J, Orkin SH
Journal Article: Genome medicine Year: 2010
Issue: 1 Volume: 2 Page: 4

Musings on genome medicine: Hepatitis C. 

Nathan D, Orkin SH
Journal Article: Cell Year: 2009
Issue: 7 Volume: 139 Page: 1303-14

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. 

Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH
Journal Article: Genome medicine Year: 2009
Issue: 12 Volume: 1 Page: 114

Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. 

Nathan D, Orkin SH
Journal Article: Molecular cell Year: 2009
Issue: 4 Volume: 36 Page: 682-95

Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. 

Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor A
Journal Article: Genome medicine Year: 2009
Issue: 11 Volume: 1 Page: 103

Musings on genome medicine: Crohn's disease. 

Nathan D, Orkin SH
Journal Article: The Journal of biological chemistry Year: 2009
Issue: 43 Volume: 284 Page: 29310-9

Translational isoforms of FOG1 regulate GATA1-interacting complexes. 

Snow JW, Orkin SH
Journal Article: Genome medicine Year: 2009
Issue: 10 Volume: 1 Page: 94

Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. 

Nathan D, Orkin SH
Journal Article: Cell stem cell Year: 2009
Issue: 4 Volume: 5 Page: 442-9

DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. 

Trowbridge JJ, Snow JW, Kim J, Orkin SH
Journal Article: Genome medicine Year: 2009
Issue: 9 Volume: 1 Page: 86

Musings on genome medicine: the Obama effect redux. 

Nathan D, Orkin SH
Journal Article: Molecular and cellular biology Year: 2009
Issue: 18 Volume: 29 Page: 5168-80

GATA-2 reinforces megakaryocyte development in the absence of GATA-1. 

Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD
Journal Article: Nature Year: 2009
Issue: 7259 Volume: 460 Page: 1093-7

Developmental and species-divergent globin switching are driven by BCL11A. 

Sankaran V, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH
Journal Article: Cell stem cell Year: 2009
Issue: 1 Volume: 5 Page: 43-53

TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. 

Schindler JW, Van Buren D, Foudi A, Krejci O, Qin J, Orkin SH, Hock H
Journal Article: Genome medicine Year: 2009
Issue: 6 Volume: 1 Page: 60

Musings on genome medicine: cholesterol and coronary artery disease. 

Nathan D, Orkin SH
Journal Article: Genome medicine Year: 2009
Issue: 5 Volume: 1 Page: 49

Musings on genome medicine: cancer genetics and the promise of effective treatment. 

Nathan D, Orkin SH
Journal Article: Blood Year: 2009
Issue: 15 Volume: 113 Page: 3461-71

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. 

Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK
Journal Article: Genome medicine Year: 2009
Issue: 4 Volume: 1 Page: 38

Musings on genome medicine: gene therapy. 

Nathan D, Orkin SH
Journal Article: Genes & development Year: 2009
Issue: 7 Volume: 23 Page: 837-48

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. 

Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ
Journal Article: Genome medicine Year: 2009
Issue: 3 Volume: 1 Page: 30

Musings on genome medicine: the Obama effect. 

Nathan D, Orkin SH
Journal Article: Current protocols in stem cell biology Year: 2009
Volume: Chapter 1 Page: Unit1B.5

Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. 

Wang J, Cantor A, Orkin SH
Journal Article: Genome medicine Year: 2009
Issue: 2 Volume: 1 Page: 18

Musings on genome medicine: abuse of genetic tests. 

Nathan D, Orkin SH
Journal Article: Genome medicine Year: 2009
Issue: 1 Volume: 1 Page: 3

Musings on genome medicine: genome wide association studies. 

Nathan D, Orkin SH
Journal Article: Cell stem cell Year: 2009
Issue: 1 Volume: 4 Page: 1-2

Glimpses of the epigenetic landscape. 

Shen X, Orkin SH
Journal Article: Nature immunology Year: 2009
Issue: 1 Volume: 10 Page: 109-15

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. 

Hartner JC, Walkley CR, Lu J, Orkin SH
Journal Article: Nature protocols Year: 2009
Issue: 4 Volume: 4 Page: 506-17

Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. 

Kim J, Cantor A, Orkin SH, Wang J
Journal Article: Science (New York, N.Y.) Year: 2008
Issue: 5909 Volume: 322 Page: 1839-42

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. 

Sankaran V, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn J, Cantor A, Orkin SH
Journal Article: Molecular cell Year: 2008
Issue: 4 Volume: 32 Page: 491-502

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. 

Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH
Journal Article: Developmental cell Year: 2008
Issue: 5 Volume: 15 Page: 668-79

Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. 

Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH, Peters AH
Journal Article: Developmental biology Year: 2008
Issue: 1 Volume: 322 Page: 179-89

GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. 

Beuling E, Bosse T, de aan Kerk DJ, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand R, Krasinski SD
Journal Article: Cell division Year: 2008
Volume: 3 Page: 13

Rb and hematopoiesis: stem cells to anemia. 

Walkley CR, Sankaran V, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2008
Issue: 33 Volume: 105 Page: 11869-74

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. 

Lettre G, Sankaran V, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn J, Orkin SH
Journal Article: Genes & development Year: 2008
Issue: 12 Volume: 22 Page: 1662-76

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. 

Walkley CR, Qudsi R, Sankaran V, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH
Journal Article: Molecular and cellular biology Year: 2008
Issue: 12 Volume: 28 Page: 3967-78

Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. 

Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2008
Issue: 17 Volume: 105 Page: 6326-31

Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. 

Wang J, Levasseur DN, Orkin SH
Journal Article: Nature genetics Year: 2008
Issue: 4 Volume: 40 Page: 411-20

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. 

Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH
Journal Article: Cell Year: 2008
Issue: 6 Volume: 132 Page: 1049-61

An extended transcriptional network for pluripotency of embryonic stem cells. 

Kim J, Chu J, Shen X, Wang J, Orkin SH
Journal Article: The Journal of experimental medicine Year: 2008
Issue: 3 Volume: 205 Page: 611-24

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. 

Cantor A, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH
Journal Article: Cell stem cell Year: 2008
Issue: 3 Volume: 2 Page: 252-63

The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. 

Rhodes KE, Gekas C, Wang Y, Lux CT, Francis CS, Chan DN, Conway S, Orkin SH, Yoder MC, Mikkola HK
Journal Article: Genes & development Year: 2008
Issue: 5 Volume: 22 Page: 575-80

Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. 

Levasseur DN, Wang J, Dorschner MO, Stamatoyannopoulos JA, Orkin SH
Journal Article: Cell Year: 2008
Issue: 4 Volume: 132 Page: 631-44

Hematopoiesis: an evolving paradigm for stem cell biology. 

Orkin SH, Zon L
Journal Article: Cell Year: 2008
Issue: 4 Volume: 132 Page: 712

SnapShot: hematopoiesis. 

Orkin SH, Zon L
Journal Article: Genes & development Year: 2008
Issue: 4 Volume: 22 Page: 463-75

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. 

Sankaran V, Orkin SH, Walkley CR
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2008
Issue: 5 Volume: 105 Page: 1620-5

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. 

Uda M, Galanello R, Sanna S, Lettre G, Sankaran V, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn J, Orkin SH, Abecasis GR, Schlessinger D, Cao A
Journal Article: Cells, tissues, organs Year: 2008
Issue: 1-2 Volume: 188 Page: 23-30

A protein roadmap to pluripotency and faithful reprogramming. 

Wang J, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2007
Issue: 52 Volume: 104 Page: 20850-5

Site-directed, virus-free, and inducible RNAi in embryonic stem cells. 

Wang J, Theunissen TW, Orkin SH
Journal Article: Cancer cell Year: 2007
Issue: 6 Volume: 12 Page: 542-58

ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. 

Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim S, Bronson RT, Perou CM, Sorensen PH, Orkin SH
Other: Nature Year: 2007
Issue: 7161 Volume: 449 Page: 410-1

Immunology: changed destiny. 

Xie H, Orkin SH
Conference Proceeding: Cell stem cell Year: 2007
Issue: 3 Volume: 1 Page: 271-6

Stem cells down under-ISSCR 2007. 

Orkin SH, Pera M
Journal Article: Molecular cell Year: 2007
Issue: 4 Volume: 27 Page: 562-72

Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. 

Saleque S, Kim J, Rooke HM, Orkin SH
Journal Article: Nature Year: 2007
Issue: 7147 Volume: 447 Page: 1007-11

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. 

North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley G, Orkin SH, Zon L
Journal Article: Cell Year: 2007
Issue: 6 Volume: 129 Page: 1081-95

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. 

Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH
Journal Article: American journal of respiratory cell and molecular biology Year: 2007
Issue: 4 Volume: 36 Page: 391-7

Gata4 is necessary for normal pulmonary lobar development. 

Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR
Journal Article: Blood Year: 2007
Issue: 4 Volume: 109 Page: 1460-71

The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. 

Ghinassi B, Sanchez M, Martelli F, Amabile G, Vannucchi AM, Migliaccio G, Orkin SH, Migliaccio AR
Journal Article: Cell Year: 2006
Issue: 6 Volume: 127 Page: 1137-50

Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. 

Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH
Journal Article: Nature Year: 2006
Issue: 7117 Volume: 444 Page: 364-8

A protein interaction network for pluripotency of embryonic stem cells. 

Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH
Journal Article: Development (Cambridge, England) Year: 2006
Issue: 19 Volume: 133 Page: 3733-44

The journey of developing hematopoietic stem cells. 

Mikkola HK, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2006
Issue: 24 Volume: 103 Page: 9057-62

Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. 

Walkley CR, Orkin SH
Journal Article: The Journal of biological chemistry Year: 2006
Issue: 19 Volume: 281 Page: 13733-42

Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1. 

Guyot B, Murai K, Fujiwara Y, Valverde-Garduno V, Hammett M, Wells S, Dear N, Orkin SH, Porcher C, Vyas P
Journal Article: Journal of immunology (Baltimore, Md. : 1950) Year: 2006
Issue: 9 Volume: 176 Page: 5267-75

Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors. 

de Pooter RF, Schmitt TM, de la Pompa JL, Fujiwara Y, Orkin SH, Zúñiga-Pflücker JC
Journal Article: Blood Year: 2006
Issue: 9 Volume: 107 Page: 3527-30

Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. 

Rooke HM, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2006
Issue: 9 Volume: 103 Page: 3339-44

Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. 

Bourquin JP, Subramanian A, Langebrake C, Reinhardt D, Bernard O, Ballerini P, Baruchel A, Cavé H, Dastugue N, Hasle H, Kaspers GL, Lessard M, Michaux L, Vyas P, van Wering E, Zwaan CM, Golub T, Orkin SH
Letter (to Editor/Journal): Science (New York, N.Y.) Year: 2006
Issue: 5761 Volume: 311 Page: 606-7

Reactions to the Hwang scandal. 

Orkin SH
Journal Article: Genome biology Year: 2006
Issue: 8 Volume: 7 Page: 230

Unraveling the transcriptional network controlling ES cell pluripotency. 

Rao S, Orkin SH
Journal Article: Current opinion in hematology Year: 2006
Issue: 1 Volume: 13 Page: 1-6

Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. 

Hock H, Orkin SH
Journal Article: Nature Year: 2005
Issue: 7066 Volume: 438 Page: 360-3

Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. 

Muroyama Y, Fujiwara Y, Orkin SH, Rowitch DH
Journal Article: Cell Year: 2005
Issue: 6 Volume: 122 Page: 828-30

Chipping away at the embryonic stem cell network. 

Orkin SH
Journal Article: Molecular and cellular biology Year: 2005
Issue: 17 Volume: 25 Page: 7412-22

Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. 

Kadri Z, Maouche-Chretien L, Rooke HM, Orkin SH, Romeo PH, Mayeux P, Leboulch P, Chretien S
Journal Article: Experimental hematology Year: 2005
Issue: 9 Volume: 33 Page: 1048-54

Placenta as a site for hematopoietic stem cell development. 

Mikkola HK, Gekas C, Orkin SH, Dieterlen-Lievre F
Journal Article: EMBO reports Year: 2005
Issue: 9 Volume: 6 Page: 879-84

The transcription factor GATA2 regulates differentiation of brown adipocytes. 

Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS
Journal Article: Blood Year: 2005
Issue: 2 Volume: 106 Page: 477-84

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. 

Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, Enver T, Vyas P, Scadden DT
Journal Article: Science (New York, N.Y.) Year: 2005
Issue: 5729 Volume: 308 Page: 1794-8

Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. 

Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh C
Other: Nature Year: 2005
Issue: 7042 Volume: 435 Page: 573-5

Stem cells: the road not taken. 

Hock H, Orkin SH
Journal Article: Nature genetics Year: 2005
Issue: 6 Volume: 37 Page: 613-9

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. 

Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH
Journal Article: Blood Year: 2005
Issue: 10 Volume: 105 Page: 3871-4

Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. 

Schlaeger T, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH
Journal Article: Developmental cell Year: 2005
Issue: 3 Volume: 8 Page: 365-75

The placenta is a niche for hematopoietic stem cells. 

Gekas C, Dieterlen-Lièvre F, Orkin SH, Mikkola HK
Journal Article: Seminars in cell & developmental biology Year: 2005
Issue: 1 Volume: 16 Page: 117-28

Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. 

Cantor A, Orkin SH
Journal Article: Stem cells (Dayton, Ohio) Year: 2005
Issue: 1 Volume: 23 Page: 134-43

Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. 

Tsuneto M, Tominaga A, Yamazaki H, Yoshino M, Orkin SH, Hayashi S
Journal Article: Methods in molecular medicine Year: 2005
Volume: 105 Page: 3-22

Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. 

Mikkola HK, Orkin SH
Journal Article: Nature Year: 2004
Issue: 7011 Volume: 431 Page: 1002-7

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. 

Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH
Journal Article: The Journal of experimental medicine Year: 2004
Issue: 7 Volume: 200 Page: 871-82

GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. 

Ling KW, Ottersbach K, van Hamburg JP, Oziemlak A, Tsai FY, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E
Journal Article: Genes & development Year: 2004
Issue: 19 Volume: 18 Page: 2336-41

Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. 

Hock H, Meade E, Medeiros S, Schindler JW, Valk PJ, Fujiwara Y, Orkin SH
Journal Article: Genome research Year: 2004
Issue: 10B Volume: 14 Page: 2162-8

Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. 

Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, van den Heuvel S, Vidal M
Journal Article: Science (New York, N.Y.) Year: 2004
Issue: 5691 Volume: 305 Page: 1776-9

A critical role for eosinophils in allergic airways remodeling. 

Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C
Journal Article: Molecular and cellular biology Year: 2004
Issue: 17 Volume: 24 Page: 7491-502

Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. 

Schlaeger T, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C
Journal Article: PLoS biology Year: 2004
Issue: 8 Volume: 2 Page: E237

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. 

Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon L
Journal Article: The Journal of biological chemistry Year: 2004
Issue: 22 Volume: 279 Page: 23597-605

Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. 

Garriga-Canut M, Orkin SH
Journal Article: Cancer cell Year: 2004
Issue: 4 Volume: 5 Page: 375-87

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. 

Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, Bronson RT, Orkin SH, DePinho RA, Jacks T
Journal Article: Molecular and cellular biology Year: 2004
Issue: 5 Volume: 24 Page: 2074-82

Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. 

Hahm K, Sum EY, Fujiwara Y, Lindeman GJ, Visvader JE, Orkin SH
Journal Article: Molecular and cellular biology Year: 2004
Issue: 3 Volume: 24 Page: 1168-73

More than blood, a novel gene required for mammalian postimplantation development. 

Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD
Journal Article: Nature reviews. Cancer Year: 2004
Issue: 2 Volume: 4 Page: 133-42

The SWI/SNF complex--chromatin and cancer. 

Roberts C, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2004
Issue: 4 Volume: 101 Page: 980-5

Coregulator-dependent facilitation of chromatin occupancy by GATA-1. 

Pal S, Cantor A, Johnson KD, Moran TB, Boyer ME, Orkin SH, Bresnick EH
Journal Article: Blood Year: 2004
Issue: 2 Volume: 103 Page: 583-5

Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. 

Fujiwara Y, Chang AN, Williams AM, Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2003
Issue: 24 Volume: 100 Page: 14030-5

Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. 

Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH
Journal Article: Immunity Year: 2003
Issue: 5 Volume: 19 Page: 633-4

Priming the hematopoietic pump. 

Orkin SH
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2003
Issue: 20 Volume: 100 Page: 11451-6

Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. 

Fossett N, Hyman K, Gajewski K, Orkin SH, Schulz RA
Journal Article: Nature Year: 2003
Issue: 6948 Volume: 424 Page: 561-5

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. 

Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH, Van Etten RA
Journal Article: The Journal of experimental medicine Year: 2003
Issue: 3 Volume: 197 Page: 281-96

GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. 

Migliaccio AR, Rana RA, Sanchez M, Lorenzini R, Centurione L, Bianchi L, Vannucchi AM, Migliaccio G, Orkin SH
Journal Article: Nature Year: 2003
Issue: 6922 Volume: 421 Page: 547-51

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. 

Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger T, Fujiwara Y, Orkin SH
Journal Article: Blood Year: 2003
Issue: 2 Volume: 101 Page: 508-16

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. 

Mikkola HK, Fujiwara Y, Schlaeger T, Traver D, Orkin SH
Journal Article: Immunity Year: 2003
Issue: 1 Volume: 18 Page: 109-20

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. 

Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH
Journal Article: Development (Cambridge, England) Year: 2003
Issue: 1 Volume: 130 Page: 221-32

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. 

Wallis D, Hamblen M, Zhou Y, Venken KJ, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ
Journal Article: Cancer cell Year: 2002
Issue: 5 Volume: 2 Page: 415-25

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. 

Roberts C, Leroux MM, Fleming MD, Orkin SH
Journal Article: Development (Cambridge, England) Year: 2002
Issue: 19 Volume: 129 Page: 4627-34

Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. 

Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH
Journal Article: Blood Year: 2002
Issue: 7 Volume: 100 Page: 2430-40

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. 

Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T
Journal Article: Blood Year: 2002
Issue: 6 Volume: 100 Page: 2040-5

X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. 

Yu C, Niakan KK, Matsushita M, Stamatoyannopoulos G, Orkin SH, Raskind WH
Journal Article: Genes & development Year: 2002
Issue: 17 Volume: 16 Page: 2207-12

Dysregulation of protein modification by ISG15 results in brain cell injury. 

Ritchie KJ, Malakhov MP, Hetherington CJ, Zhou L, Little MT, Malakhova OA, Sipe JC, Orkin SH, Zhang DE
Journal Article: Proceedings of the National Academy of Sciences of the United States of America Year: 2002
Issue: 14 Volume: 99 Page: 9237-42

GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. 

Chang AN, Cantor A, Fujiwara Y, Lodish MB, Droho S, Crispino JD, Orkin SH
Other: Nature Year: 2002
Issue: 6893 Volume: 418 Page: 25-7

Stem-cell competition. 

Orkin SH, Morrison SJ
Journal Article: The Journal of experimental medicine Year: 2002
Issue: 11 Volume: 195 Page: 1387-95

Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. 

Yu C, Cantor A, Yang H, Browne C, Wells RA, Fujiwara Y, Orkin SH
Journal Article: Molecular and cellular biology Year: 2002
Issue: 12 Volume: 22 Page: 4268-79

Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. 

Cantor A, Katz SG, Orkin SH
Journal Article: Oncogene Year: 2002
Issue: 21 Volume: 21 Page: 3368-76

Transcriptional regulation of erythropoiesis: an affair involving multiple partners. 

Cantor A, Orkin SH
Journal Article: Molecular and cellular biology Year: 2002
Issue: 9 Volume: 22 Page: 3121-8

Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. 

Katz SG, Cantor A, Orkin SH
Journal Article: Nature immunology Year: 2002
Issue: 4 Volume: 3 Page: 323-8

Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. 

Orkin SH, Zon L
Journal Article: Journal of hematotherapy & stem cell research Year: 2002
Issue: 1 Volume: 11 Page: 9-17

The search for the hemangioblast. 

Mikkola HK, Orkin SH
Journal Article: Genes & development Year: 2002
Issue: 3 Volume: 16 Page: 301-6

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. 

Saleque S, Cameron S, Orkin SH
Journal Article: Methods (San Diego, Calif.) Year: 2002
Issue: 1 Volume: 26 Page: 84-92

The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. 

Crispino JD, Orkin SH