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Active Grants and Sponsored Research

Sponsor Grant ID: 2P01HL048546-21A1 Project Date: September 01, 2016 - May 31, 2021
Sponsoring Organization: Oregon Health and Science University

Preclinical Studies of Marrow Failure and Clonal Evolution in Fanconi Anemia

Description of Major Goals
Evaluate the effects of small molecule compounds, metformin and TGF-beta receptor kinase inhibitors that improve proliferation, hematopoiesis, and cell survival in Fanconia anemia models.
Sponsor Grant ID: 5R01DK103854-02 Project Date: December 01, 2015 - November 30, 2019
Sponsoring Organization: National Institute of Diabetes and Digestive and Kidney Diseases

U2AF1 mutations in myelodysplastic syndromes: from mechanism to therapy

Description of Major Goals
The goal of this study is to determine the mechanistic and functional consequences of U2AF1 spliceosomal mutations in order to identify new therapeutic strategies. The specific aims are: 1) Determine the mechanistic basis and consequences of the observed genetic spectrum of U2AF1 mutations; 2) Determine how U2AF1 mutations dysregulate downstream molecular pathways, contributing to molecular features of dysplastic cells. 3) Identify potential therapeutic opportunities for targeting U2AF1-mutant cells.
Sponsor Grant ID: Research Award Project Date: October 01, 2015 - September 30, 2018
Sponsoring Organization: Leukemia & Lymphoma Society

Modeling MDS and Leukemia Predisposition for Novel Therapeutics

Description of Major Goals
The specific aim of this study is to identify small molecule compounds that target del7q clones in Shwachman Diamond Syndrome.
Sponsor Grant ID: 5R24DK099808-05 Project Date: September 29, 2013 - August 31, 2018
Sponsoring Organization: National Institute of Diabetes and Digestive and Kidney Diseases

Translational Studies of Inherited Marrow Failure and Myelodysplastic Syndromes

Description of Major Goals
This is a resource development and discovery grant investigating inherited marrow failure and familial myelodysplastic syndromes with a focus on gene discovery.
Sponsor Grant ID: W81XWH-16-1-0054 Project Date: February 15, 2016 - February 25, 2018
Sponsoring Organization: Department of Defense

Modeling Marrow Failure and MDS for Novel Therapeutics

Description of Major Goals
The goal of this study is to conduct a functional genomics screen to identify genes and molecular pathways that improve hematopoiesis and inhibit del7q cytogenetic clones arising in the context of bone marrow failure